ArticleHorticulture research2021
Genomic analysis uncovers functional variation in the C-terminus of anthocyanin-activating MYB transcription factors.
Article in Horticulture research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Evolutionary and functional divergence of MYB regulatory networks in flavonoid biosynthesis across Poaceae, non-Poaceae monocots, and eudicot horticultural plants.Horticulture research · 2026Review
- LlR3MYB-mediated flavonoid biosynthesis confers cold stress tolerance inHorticulture research · 2026Article
- The RcMYB308-RcEGL1 module regulates cyanidin accumulation by targeting the RcF3'H promoter in pink roses.BMC plant biology · 2026Article
- Multifaceted roles and regulatory mechanisms of MYB transcription factors in plant development, secondary metabolism, and stress adaptation: current insights and future prospects.GM crops & food · 2025Review
- Evolutionary dynamics of Orchid DL paralogs: gene duplication, functional divergence, and expression patterns across Orchid subfamilies.BMC plant biology · 2025Article
- Evolutionary trajectory of transcription factors and selection of targets for metabolic engineering.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Integrated metabolomic and transcriptomic analysis reveals biosynthesis mechanism of flavone and caffeoylquinic acid in chrysanthemum.BMC genomics · 2024Article
- Article
- Graph-Based Pangenome of Actinidia chinensis Reveals Structural Variations Mediating Fruit Degreening.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Analyzing the Diversity of MYB Family Response Strategies to Drought Stress in Different Flax Varieties Based on Transcriptome Data.Plants (Basel, Switzerland) · 2024Article
- Overexpression of a 'Beta' MYB Factor Gene,International journal of molecular sciences · 2024Article
- The R2R3-MYB transcription factor EVER controls the emission of petunia floral volatiles by regulating epicuticular wax biosynthesis in the petal epidermis.The Plant cell · 2023Article
- Molecular insights into the VIRESCENS amino acid sequence and its implication in anthocyanin production in red- and yellow-fruited cultivars of date palm.Scientific reports · 2023Article
- Overexpression of a Grape MYB Transcription Factor GeneInternational journal of molecular sciences · 2023Article
- The MYB transcription factor RcMYB1 plays a central role in rose anthocyanin biosynthesis.Horticulture research · 2023Article
- Novel R2R3 MYB transcription factors regulate anthocyanin synthesis in Aubergine tomato plants.BMC plant biology · 2023Article
- Large-scale analysis of putative Euphorbiaceae R2R3-MYB transcription factors identifies a MYB involved in seed oil biosynthesis.BMC plant biology · 2023Article
- MYB30 and MYB14 form a repressor-activator module with WRKY8 that controls stilbene biosynthesis in grapevine.The Plant cell · 2023Article
- Transcriptome Analysis Reveals Roles of Sucrose in Anthocyanin Accumulation in 'Kuerle Xiangli' (Genes · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MYB transcription factors regulate diverse aspects of plant development and secondary metabolism, often by partnering in transcriptional regulatory complexes. Here, we harness genomic resources to identify novel MYBs, thereby producing an updated eudicot MYB phylogeny with revised relationships among subgroups as well as new information on sequence variation in the disordered C-terminus of anthocyanin-activating MYBs. BLAST® and hidden Markov model scans of gene annotations identified a total of 714 MYB transcription factors across the genomes of four crops that span the eudicots: apple, grape, kiwifruit and tomato. Codon model-based phylogenetic inference identified novel members of previously defined subgroups, and the function of specific anthocyanin-activating subgroup 6 members was assayed transiently in tobacco leaves. Sequence conservation within subgroup 6 highlighted one previously described and two novel short linear motifs in the disordered C-terminal region. The novel motifs have a mix of hydrophobic and acidic residues and are predicted to be relatively ordered compared with flanking protein sequences. Comparison of motifs with the Eukaryotic Linear Motif database suggests roles in protein-protein interaction. Engineering of motifs and their flanking regions from strong anthocyanin activators into weak activators, and vice versa, affected function. We conclude that, although the MYB C-terminal sequence diverges greatly even within MYB clades, variation within the C-terminus at and near relatively ordered regions offers opportunities for exploring MYB function and developing superior alleles for plant breeding.
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