ArticleHorticulture research2021
Differential regulation of triterpene biosynthesis induced by an early failure in cuticle formation in apple.
Article in Horticulture research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 78 citations in OpenAlex.
- Article
- Genome-wide identification of eQTL-associated lncRNAs in melon and their role in fruit cracking.Scientific reports · 2026Article
- Investigating the bHLH transcription factor TSARL1 as marker and regulator of saponin biosynthesis in Chenopodium quinoa.Journal of the science of food and agriculture · 2025Article
- Preliminary Study on the Geochemical Characterization of Viticis Fructus Cuticular Waxes: From Latitudinal Variation to Origin Authentication.International journal of molecular sciences · 2025Article
- Multiomics reveals the molecular mechanism of unsaturated fatty acid-induced terpenoid biosynthesis in Sanghuangporus lonicericola.NPJ science of food · 2025Article
- Review
- Natural variation in MdNAC5 contributes to fruit firmness and ripening divergence in apple.Horticulture research · 2025Article
- Diploid genome assembly of the Malbec grapevine cultivar enables haplotype-aware analysis of transcriptomic differences underlying clonal phenotypic variation.Horticulture research · 2024Article
- NACs strike again: NOR-like1 is responsible for cuticle development in tomato fruit.Journal of experimental botany · 2024Article
- Uncovering the molecular mechanisms of russet skin formation in Niagara grapevine (Vitis vinifera × Vitis labrusca).Scientific reports · 2024Article
- Plant In Vitro Culture Factories for Pentacyclic Triterpenoid Production.Advances in biochemical engineering/biotechnology · 2024Review
- Time course of changes in the transcriptome during russet induction in apple fruit.BMC plant biology · 2023Article
- Characterization of MdMYB68, a suberin master regulator in russeted apples.Frontiers in plant science · 2023Article
- Molecular mechanisms involved in fruit cracking: A review.Frontiers in plant science · 2023Review
- Gene expression profile during seed development ofFrontiers in plant science · 2023Article
- Multiplex knockout of trichome-regulating MYB duplicates in hybrid poplar using a single gRNA.Plant physiology · 2022Article
- Identification of Novel Candidate Genes Involved in Apple Cuticle Integrity and Russeting-Associated Triterpene Synthesis Using Metabolomic, Proteomic, and Transcriptomic Data.Plants (Basel, Switzerland) · 2022Article
- Transcriptional regulation of KCS gene by bZIP29 and MYB70 transcription factors during ABA-stimulated wound suberization of kiwifruit (Actinidia deliciosa).BMC plant biology · 2022Article
- MdMYB52 regulates lignin biosynthesis upon the suberization process in apple.Frontiers in plant science · 2022Article
- Advances in Understanding the Causes, Molecular Mechanism, and Perspectives of Russeting on Tree Fruit.Frontiers in plant science · 2022Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Waxy apple cuticles predominantly accumulate ursane-type triterpenes, but the profile shifts with the induction of skin russeting towards lupane-type triterpenes. We previously characterised several key enzymes in the ursane-type and lupane-type triterpene pathways, but this switch in triterpene metabolism associated with loss of cuticle integrity is not fully understood. To analyse the relationship between triterpene biosynthesis and russeting, we used microscopy, RNA-sequencing and metabolite profiling during apple fruit development. We compared the skin of three genetically-close clones of 'Golden Delicious' (with waxy, partially russeted and fully russeted skin). We identified a unique molecular profile for the russet clone, including low transcript abundance of multiple cuticle-specific metabolic pathways in the early stages of fruit development. Using correlation analyses between gene transcription and metabolite concentration we found MYB transcription factors strongly associated with lupane-type triterpene biosynthesis. We showed how their transcription changed with the onset of cuticle cracking followed by russeting and that one factor, MYB66, was able to bind the promoter of the oxidosqualene cyclase OSC5, to drive the production of lupeol derivatives. These results provide insights into the breakdown of cuticle integrity leading to russet and how this drives MYB-regulated changes to triterpene biosynthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.