ArticleHorticulture research2021
Building a cluster of NLR genes conferring resistance to pests and pathogens: the story of the Vat gene cluster in cucurbits.
Article in Horticulture research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- Identification and molecular mapping of a new Hessian fly resistance gene in the spring barley variety 'Golf'.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- A comprehensive analysis of two Chinese cucumber genomes and a mutant population as resources for precision breeding.Horticulture research · 2026Article
- Comparative analysis of PRR receptors and R genes reveals structural and functional divergence between wild, ancestral, and commercial citrus species.BMC genomics · 2026Article
- Ancient pangenomic origins of noncanonical NLR genes underlying the recent evolutionary rescue of a staple crop.Science advances · 2025Article
- Nuclear and organelle genome assemblies of 5 Cucumis melo L. accessions, Ananas, Canton, PI 414723, Vedrantais, and Zhimali, belonging to diverse botanical groups.G3 (Bethesda, Md.) · 2025Article
- Nanopore adaptive sampling to identify the NLR gene family in melon (Cucumis melo L.).BMC genomics · 2025Article
- Unlocking the potential of 'Egusi' melon (Frontiers in plant science · 2025Review
- Identification of Powdery Mildew Resistance-Related Genes in Butternut Squash (International journal of molecular sciences · 2024Article
- Disease resistance gene count increases with rainfall inEcology and evolution · 2024Article
- Possibility of genome editing for melon breeding.Breeding science · 2024Article
- The melonPlant direct · 2024Article
- A highly diversified NLR cluster in melon contains homologs that confer powdery mildew and aphid resistance.Horticulture research · 2024Article
- The haplotype-resolved T2T reference genome highlights structural variation underlying agronomic traits of melon.Horticulture research · 2023Article
- Aphid adaptation to cucurbits: sugars, cucurbitacin and phloem structure in resistant and susceptible melons.BMC plant biology · 2023Article
- The chromosome-scale reference genome and transcriptome analysis ofFrontiers in plant science · 2023Article
- A cluster of atypical resistance genes in soybean confers broad-spectrum antiviral activity.Plant physiology · 2022Article
- Comparative transcriptomics and genomic analyses reveal differential gene expression related toFrontiers in plant science · 2022Article
- Review
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Most molecularly characterized plant resistance genes (R genes) belong to the nucleotide-binding-site-leucine-rich-repeat (NLR) receptor family and are prone to duplication and transposition with high sequence diversity. In this family, the Vat gene in melon is one of the few R genes known for conferring resistance to insect, i.e., Aphis gossypii, but it has been misassembled and/or mispredicted in the whole genomes of Cucurbits. We examined 14 genomic regions (about 400 kb) derived from long-read assemblies spanning Vat-related genes in Cucumis melo, Cucumis sativus, Citrullus lanatus, Benincasa hispida, Cucurbita argyrosperma, and Momordica charantia. We built the phylogeny of those genes. Investigating the paleohistory of the Vat gene cluster, we revealed a step by step process beginning from a common ancestry in cucurbits older than 50 my. We highlighted Vat exclusively in the Cucumis genera, which diverged about 20 my ago. We then focused on melon, evaluating a minimum duplication rate of Vat in 80 wild and cultivated melon lines using generalist primers; our results suggested that duplication started before melon domestication. The phylogeny of 44 Vat-CDS obtained from 21 melon lines revealed gain and loss of leucine-rich-repeat domains along diversification. Altogether, we revealed the high putative recognition scale offered in melon based on a combination of SNPs, number of leucine-rich-repeat domains within each homolog and number of homologs within each cluster that might jointly confer resistance to a large pest and pathogen spectrum. Based on our findings, we propose possible avenues for breeding programs.
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