Evidence map›Paper›PMID 33789939›Full record

ArticlemSphere2021

Escherichia coli Nissle 1917 Enhances Innate and Adaptive Immune Responses in a Ciprofloxacin-Treated Defined-Microbiota Piglet Model of Human Rotavirus Infection.

Husheem Michael, Francine C Paim, Stephanie N Langel, Ayako Miyazaki, David D Fischer, Juliet Chepngeno, Joshua Amimo, Loic Deblais, Gireesh Rajashekara, Linda J Saif and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
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  9. Article
  10. Effects ofIranian journal of veterinary research · 2023
    Article
  11. Article
  12. Vaccines · 2022
    Article
  13. Review
  14. Review
  15. Effects ofFrontiers in microbiology · 2022
    Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Husheem MichaelFood Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA.
Francine C PaimFood Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA.
Stephanie N LangelFood Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA.
Ayako MiyazakiFood Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA.
David D FischerFood Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA.
Juliet ChepngenoFood Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA.
Joshua AmimoFood Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA.
Loic DeblaisFood Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA.
Gireesh RajashekaraFood Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA.
Linda J SaifFood Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA saif.2@osu.edu vlasova.1@osu.edu.ORCID 0000-0002-3224-9009
Anastasia N VlasovaFood Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA saif.2@osu.edu vlasova.1@osu.edu.ORCID 0000-0002-1447-6283
The Ohio State University · USNational Agriculture and Food Research Organization · JP

Funding

Gut microflora: Impact on neonatal immunity, viral gastroenteritis and vaccinesR01AI099451 · NIAID · OHIO STATE UNIVERSITY · PI RAJASHEKARA, GIREESH, SAIF, LINDA J. · 2012 to 2016
$2.2M
NIAID NIH HHS R01 AI099451
6 · The paper itself

Abstract

Human rotavirus (HRV) infection is a major cause of gastroenteritis in children worldwide. Broad-spectrum antibiotic-induced intestinal microbial imbalance and the ensuing immune-metabolic dysregulation contribute to the persistence of HRV diarrhea.

Indexed as

Adaptive ImmunityImmunity, InnateAge FactorsAnimalsAnti-Bacterial AgentsCiprofloxacinCytokinesDisease Models, AnimalEscherichia coliGastrointestinal MicrobiomeHumansProbioticsRotavirusRotavirus InfectionsSwineAnti-Bacterial AgentsCiprofloxacinCytokinesadaptive immunityciprofloxacincommensal microbiotagnotobiotic pigshuman rotavirus infectioninnate immunityprobiotics

Identifiers

PMID33789939
PMCPMC8546683
OpenAlexW3143351535

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.