ReviewJournal of neurology, neurosurgery, and psychiatry2021
Prognostic predictors relevant to end-of-life palliative care in Parkinson's disease and related disorders: a systematic review.
Review in Journal of neurology, neurosurgery, and psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Prognostic factors of survival in corticobasal syndrome and corticobasal degeneration: A scoping review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Dietary tributyrin supplementation in Parkinson's disease: An open-label target engagement study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Far from being the end of the road: taking a closer look at neuropalliative care in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Effects of specialised physiotherapy on mortality in Parkinson's disease: a prospective observational study.NPJ Parkinson's disease · 2025Article
- Nursing contribution to end-of-life care decision-making in patients with neurological diseases on an acute hospital ward: documentation of signs and symptoms.BMC nursing · 2025Article
- Linear predictive coding electroencephalography algorithms predict mortality in Parkinson's disease.Clinical parkinsonism & related disorders · 2025Article
- Care of the Patient Nearing the End of Life in the Neurointensive Care Unit.Neurocritical care · 2024Review
- Health care utilization at the end of life in Parkinson's disease: a population-based register study.BMC palliative care · 2024Article
- Gender-Specific Differences in Spinal Alignment and Muscle Power in Patients with Parkinson's Disease.Diagnostics (Basel, Switzerland) · 2024Article
- Tackling vascular risk factors as a possible disease modifying intervention in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Update: Descriptive epidemiology of Parkinson disease.Parkinsonism & related disorders · 2024Review
- Retrospective analyses evaluating the mortality risk associated with pimavanserin or other atypical antipsychotics in patients with Parkinson disease psychosis.Clinical parkinsonism & related disorders · 2024Review
- The "Surprise Question" for Prognostication in People With Parkinson's Disease and Related Disorders.Journal of pain and symptom management · 2024Article
- Terminal Care in Parkinson's Disease: Real-Life Use of Continuous Subcutaneous Apomorphine Infusion to Improve Patient Comfort.Journal of Parkinson's disease · 2024Article
- Palliative Care of End Stage Parkinsonism: An Overview Including the Five Pillars Framework.Movement disorders clinical practice · 2023Article
- End of life care of hospitalized patients with Parkinson disease: a retrospective analysis and brief review.Frontiers in aging neuroscience · 2023Article
- Relationship between Lower Limbs Performance and Spinal Alignment in Parkinson's Disease Patients: An Observational Study with Cross Sectional Design.Journal of clinical medicine · 2022Article
- Triggers for Referral to Specialized Palliative Care in Advanced Neurologic and Neurosurgical Conditions: A Systematic Review.Neurology. Clinical practice · 2022Article
- Parkinson's disease and Covid-19: Is there an impact of ethnicity and the need for palliative care.International review of neurobiology · 2022Article
- Management of advanced Parkinson's disease in Israel: Clinicians viewpoint and action items.Frontiers in aging neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
Parkinson's disease and related disorders (PDRD) are the second most common neurodegenerative disease and a leading cause of death. However, patients with PDRD receive less end-of-life palliative care (hospice) than other illnesses, including other neurologic illnesses. Identification of predictors of PDRD mortality may aid in increasing appropriate and timely referrals. To systematically review the literature for causes of death and predictors of mortality in PDRD to provide guidance regarding hospice/end-of-life palliative care referrals. We searched MEDLINE, PubMed, EMBASE and CINAHL databases (1970-2020) of original quantitative research using patient-level, provider-level or caregiver-level data from medical records, administrative data or survey responses associated with mortality, prognosis or cause of death in PDRD. Findings were reviewed by an International Working Group on PD and Palliative Care supported by the Parkinson's Foundation. Of 1183 research articles, 42 studies met our inclusion criteria. We found four main domains of factors associated with mortality in PDRD: (1) demographic and clinical markers (age, sex, body mass index and comorbid illnesses), (2) motor dysfunction and global disability, (3) falls and infections and (4) non-motor symptoms. We provide suggestions for consideration of timing of hospice/end-of-life palliative care referrals. Several clinical features of advancing disease may be useful in triggering end-of-life palliative/hospice referral. Prognostic studies focused on identifying when people with PDRD are nearing their final months of life are limited. There is further need for research in this area as well as policies that support need-based palliative care for the duration of PDRD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.