ArticleScience advances2021
Bone metabolism and evolutionary origin of osteocytes: Novel application of FIB-SEM tomography.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Cellular, bone-like tissue in the bucklers and thorns of the thornback rayProceedings. Biological sciences · 2025Article
- Article
- The Evolving Role of PTH Signaling in Osteocytes.Endocrinology · 2025Review
- Age is just a number: Examining the preservation of cells and soft tissues in Bothriolepis and other Devonian fish.PloS one · 2025Article
- Nanoscopic imaging of ancient protein and vasculature offers insight into soft tissue and biomolecule fossilization.iScience · 2024Article
- 2D vs. 3D Evaluation of Osteocyte Lacunae - Methodological Approaches, Recommended Parameters, and Challenges: A Narrative Review by the European Calcified Tissue Society (ECTS).Current osteoporosis reports · 2024Review
- Computational modeling based on confocal imaging predicts changes in osteocyte and dendrite shear stress due to canalicular loss with aging.Biomechanics and modeling in mechanobiology · 2024Article
- Simultaneous multimaterial operando tomography of electrochemical devices.Science advances · 2023Article
- The osteocyte and its osteoclastogenic potential.Frontiers in endocrinology · 2023Review
- Renal osteodystrophy: A historical review of its origins and conceptual evolution.Bone reports · 2022Review
- Use of Photobiomodulation Combined with Fibrin Sealant and Bone Substitute Improving the Bone Repair of Critical Defects.Polymers · 2022Article
- Black phosphorous nanomaterials as a new paradigm for postoperative tumor treatment regimens.Journal of nanobiotechnology · 2022Review
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lacunae and canaliculi spaces of osteocytes are remarkably well preserved in fossilized bone and serve as an established proxy for bone cells. The earliest bone in the fossil record is acellular (anosteocytic), followed by cellular (osteocytic) bone in the jawless relatives of jawed vertebrates, the osteostracans, about 400 million years ago. Virtually nothing is known about the physiological pressures that would have initially favored osteocytic over anosteocytic bone. We apply focused ion beam-scanning electron microscopy tomography combined with machine learning for cell detection and segmentation to image fossil cell spaces. Novel three-dimensional high-resolution images reveal areas of low density around osteocyte lacunae and their canaliculi in osteostracan bone. This provides evidence for demineralization that would have occurred in vivo as part of osteocytic osteolysis, a mechanism of mineral homeostasis, supporting the hypothesis that a physiological demand for phosphorus was the principal driver in the initial evolution of osteocytic bone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.