Evidence map›Paper›PMID 33789736›Full record

ArticleClinical epigenetics2021

Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood.

J R Pfeiffer, Angela C Bustamante, Grace S Kim, Don Armstrong, Annchen R Knodt, Karestan C Koenen, Ahmad R Hariri, Monica Uddin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

J R PfeifferDepartment of Psychology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Angela C BustamanteDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Grace S KimMedical Scholars Program, University of Illinois College of Medicine, Urbana, IL, USA.
Don ArmstrongCarl R. Woese Institute for Genomic Biology, Urbana, IL, USA.
Annchen R KnodtDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Karestan C KoenenDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Ahmad R HaririDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Monica UddinGenomics Program, College of Public Health, University of South Florida, 3720 Spectrum Blvd., Suite 304, Tampa, FL, USA. monica43@usf.edu.ORCID 0000-0001-7404-2068
Duke University · USUniversity of Illinois Urbana-Champaign · USHarvard University · USUniversity of Michigan · USUniversity of South Florida · USUrbana University · US

Funding

PULMONARY CELLULAR AND MOLECULAR BIOLOGY TRAININGT32HL007749 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Robert Pickett Dickson · 1993 to 2026
$19.9M
Epigenomic Predictors of PTSD and Traumatic Stress in an African American CohortR01MD011728 · NIMHD · UNIVERSITY OF SOUTH FLORIDA · PI AIELLO, ALLISON E, UDDIN, MONICA · 2017 to 2025
$5.7M
Self-Regulation Failure: Identifying and Modifying a Risk PhenotypeR01DA031579 · NIDA · DUKE UNIVERSITY · PI HARIRI, AHMAD R., STRAUMAN, TIMOTHY J · 2010 to 2012
$1.9M
Neurogenetic Pathways to Drug Use in Young AdultsR01DA033369 · NIDA · DUKE UNIVERSITY · PI HARIRI, AHMAD R. · 2013 to 2016
$1.4M
A Compute Cluster for Brain Imaging and AnalysisS10OD021480 · OD · DUKE UNIVERSITY · PI SONG, ALLEN W · 2016 to 2016
$568k
NHLBI NIH HHS T32 HL007749NIDA NIH HHS R01 DA031579NIDA NIH HHS R01 DA033369NIH HHS S10 OD021480NIMHD NIH HHS R01 MD011728
6 · The paper itself

Abstract

backgroundPoor family emotional health (FEH) during childhood is prevalent and impactful, and likely confers similar neurodevelopmental risks as other adverse social environments. Pointed FEH study efforts are underdeveloped, and the mechanisms by which poor FEH are biologically embedded are unclear. The current exploratory study examined whether variability in 5-methyl-cytosine (5mC) and fronto-limbic grey matter volume may represent pathways through which FEH may become biologically embedded.

resultsIn 98 university students aged 18-22 years, retrospective self-reported childhood FEH was associated with right hemisphere hippocampus (b = 10.4, p = 0.005), left hemisphere amygdala (b = 5.3, p = 0.009), and right hemisphere amygdala (b = 5.8, p = 0.016) volumes. After pre-processing and filtering to 5mC probes correlated between saliva and brain, analyses showed that childhood FEH was associated with 49 5mC principal components (module eigengenes; MEs) (p

conclusionsFindings extend work highlighting neurodevelopmental variability associated with adverse social environment exposure during childhood by specifically implicating poor FEH, while informing a mechanism of biological embedding. FEH-associated epigenetic signatures could function as proxies of altered fronto-limbic grey matter volume associated with poor childhood FEH and inform further investigation into primarily affected tissues such as endocrine, immune, and CNS cell types.

Indexed as

AdolescentAdultChrysenesFamily RelationsFemaleGray MatterHumansMaleRetrospective StudiesSalivaStress, PsychologicalStudentsUnited StatesYoung AdultChrysenesAdverse social environmentBiological embeddingFamily emotional healthFronto-limbicNeuroimagingPeripheral epigenetics

Identifiers

PMID33789736
PMCPMC8010979
OpenAlexW3149472503

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.