Evidence map›Paper›PMID 33789728›Full record

ArticleParasites & vectors2021

Assessment of fluralaner as a treatment in controlling Dermanyssus gallinae infestation on commercial layer farms and the potential for resulting benefits of improved bird welfare and productivity.

Ivo Petersen, Katharina Johannhörster, Eric Pagot, Damian Escribano, Eva Zschiesche, Déborah Temple, Emmanuel Thomas

Open access · goldAbstract read
In one paragraph

Article in Parasites & vectors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

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  12. Administering Fluralaner in Drinking Water for Treatment ofIranian journal of pharmaceutical research : IJPR
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ivo PetersenMSD Animal Health Innovation GmbH, Zur Propstei, 55270, Schwabenheim, Germany. ivo.petersen@msd.de.
Katharina JohannhörsterPraxis Dr. Pöppel, Drubbelstrasse 2, 33119, Delbrück, Germany.
Eric PagotCentre Technique Des Productions Animales, Zoopole Dévelopment, 2 rue Jean Rostand, 22440, Ploufragan, France.
Damian EscribanoInterdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Campus of Excellence Mare Nostrum, University of Murcia, Campus de Espinardo s/n, 30100, Murcia, Espinardo, Spain.
Eva ZschiescheMSD Animal Health Innovation GmbH, Zur Propstei, 55270, Schwabenheim, Germany.
Déborah TempleSchool of Veterinary Medicine, Universitat Autonoma de Barcelona, Bellaterra, Spain.
Emmanuel ThomasMSD Animal Health Innovation GmbH, Zur Propstei, 55270, Schwabenheim, Germany.
Orthopädische Praxis · DEUniversidad de Murcia · ESUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPoultry red mite (PRM) (Dermanyssus gallinae) infestations are a cause of anaemia, impaired productivity and stress-related behaviours linked to reduced hen welfare. A study investigated the potential health, welfare and productivity benefits following fluralaner treatment to eliminate PRM from infested hens.

methodsA PRM-infested layer house was selected on a free-range farm (5400 hens) and an aviary farm (42,400 hens). Fluralaner (Exzolt

resultsThroughout the post-treatment period, fluralaner efficacy against PRM was > 99% on both farms. On the aviary and free-range farms, treatment was followed by significant nighttime increases in the proportion of resting hens (P < 0.0001; P = 0.0175, respectively). Significant post-treatment versus pre-treatment nighttime reductions were observed in head shaking (aviary, P < 0.0001; free-range P = 0.0233) and preening (P = 0.0032; P = 0.0018) and on the aviary farm in bouts of body shaking (P = 0.0108), vertical wing shaking (P = 0.0002), head scratching (P = 0.0335), and gentle feather pecking (P < 0.0001). On the free-range farm there were significant daytime reductions in head scratching (P < 0.0001), head shaking (P = 0.0492) and preening (P = 0.0012). Relative to standard production parameters, no differences were detected on the aviary farm, but on the free-range farm the laying rate decline with increasing age was less than expected and the increase in egg weight greater than expected. Post-treatment increases in egg and plasma corticosterone were suggestive of stress factors in addition to mite infestation. Red blood cell counts and haematocrit increased following treatment.

conclusionFluralaner treatment eliminated mite challenge, leading to improved hen welfare and health, based on reductions in stress-related behaviours and restoration of the anaemia-inducing effects of mite blood feeding.

Indexed as

AnimalsChickensDrinking WaterEggsFemaleIsoxazolesMite InfestationsMitesPoultryPoultry DiseasesA1443 compoundDrinking WaterIsoxazolesDermanyssus gallinaeFluralanerHen healthHen welfareIsoxazolineLayer hensPoultry red mite

Identifiers

PMID33789728
PMCPMC8011190
OpenAlexW3144648061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.