Evidence map›Paper›PMID 33789690›Full record

ArticleJournal of translational medicine2021

Intranasal leptin improves survival after opioid overdose in a mouse model.

Carla Freire, Huy Pho, Shannon Bevans-Fonti, Luiz U Sennes, Vsevolod Y Polotsky

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Carla FreireJohns Hopkins Sleep Disorders Center, 5501 Hopkins Bayview Circle, room 5A.50, Baltimore, MD, 21224, USA. cfreire2@jhmi.edu.ORCID 0000-0001-8118-5665
Huy PhoJohns Hopkins Sleep Disorders Center, 5501 Hopkins Bayview Circle, room 5A.50, Baltimore, MD, 21224, USA.
Shannon Bevans-FontiJohns Hopkins Sleep Disorders Center, 5501 Hopkins Bayview Circle, room 5A.50, Baltimore, MD, 21224, USA.
Luiz U SennesOtolaryngology Department, University of São Paulo, Sao Paulo, Brazil.
Vsevolod Y PolotskyJohns Hopkins Sleep Disorders Center, 5501 Hopkins Bayview Circle, room 5A.50, Baltimore, MD, 21224, USA.
Johns Hopkins University · USUniversidade de São Paulo · BR

Funding

Melanocortin 4 signaling in the carotid body in obesityR01HL133100 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Vsevolod Y Polotsky, Wan-yee Tang · 2016 to 2026
$7.1M
Treatment of Sleep Apnea by Targeting Leptin SignalingR01HL128970 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MENDELOWITZ, DAVID, POLOTSKY, VSEVOLOD Y · 2015 to 2023
$5.4M
Chemogenetic approach to treat Obstructive Sleep ApneaR01HL138932 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POLOTSKY, VSEVOLOD Y · 2017 to 2020
$2.4M
Intranasal Leptin as A Novel Treatment of Opioid-Induced Respiratory DepressionR61HL156240 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POLOTSKY, VSEVOLOD Y · 2020 to 2020
$737k
Targeting Leptin Pathway to Treat Opioid-Induced Respiratory DepressionU18DA052301 · NIDA · JOHNS HOPKINS UNIVERSITY · PI POLOTSKY, VSEVOLOD Y · 2021 to 2021
$259k
Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/08758-3NHLBI NIH HHS R01 HL128970NHLBI NIH HHS R01 HL133100NHLBI NIH HHS R61 HL156240NIDA NIH HHS U18 DA052301NIH HHS R01HL 128970NIH HHS R01HL 138932NIH HHS R61 HL156240NIH HHS U18 DA052301
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

LeptinOpiate OverdoseAdministration, IntranasalAnalgesics, OpioidAnimalsDisease Models, AnimalMiceAnalgesics, OpioidLeptinBlood brain barrierLeptinOpioid overdoseOpioid reversal agents

Identifiers

PMID33789690
PMCPMC8010489
OpenAlexW3141663475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.