Evidence map›Paper›PMID 33789673›Full record

ArticleRespiratory research2021

Development and performance assessment of novel machine learning models to predict pneumonia after liver transplantation.

Chaojin Chen, Dong Yang, Shilong Gao, Yihan Zhang, Liubing Chen, Bohan Wang, Zihan Mo, Yang Yang, Ziqing Hei, Shaoli Zhou

Abstract read
In one paragraph

Article in Respiratory research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chaojin Chen *Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 10630, Guangdong, People's Republic of China.
Dong Yang *Guangzhou AID Cloud Technology Co., LTD, Guangzhou, People's Republic of China.
Shilong GaoDepartment of Information, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China.
Yihan ZhangDepartment of Anesthesiology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 10630, Guangdong, People's Republic of China.
Liubing ChenDepartment of Anesthesiology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 10630, Guangdong, People's Republic of China.
Bohan WangGuangzhou AID Cloud Technology Co., LTD, Guangzhou, People's Republic of China.
Zihan MoGuangzhou AID Cloud Technology Co., LTD, Guangzhou, People's Republic of China.
Yang YangDepartment of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, Guangdong, People's Republic of China. yysysu@163.com.
Ziqing HeiDepartment of Anesthesiology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 10630, Guangdong, People's Republic of China. heiziqing@sina.com.
Shaoli ZhouDepartment of Anesthesiology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 10630, Guangdong, People's Republic of China. 13610272308@139.com.

Funding

National Natural Science Foundation of China Grant No. 81974296Postdoctoral Science Foundation of China Grant No. 2019M663260Postdoctoral Science Foundation of China Grant No.2020T130148ZX
6 · The paper itself

Abstract

backgroundPneumonia is the most frequently encountered postoperative pulmonary complications (PPC) after orthotopic liver transplantation (OLT), which cause high morbidity and mortality rates. We aimed to develop a model to predict postoperative pneumonia in OLT patients using machine learning (ML) methods.

methodsData of 786 adult patients underwent OLT at the Third Affiliated Hospital of Sun Yat-sen University from January 2015 to September 2019 was retrospectively extracted from electronic medical records and randomly subdivided into a training set and a testing set. With the training set, six ML models including logistic regression (LR), support vector machine (SVM), random forest (RF), adaptive boosting (AdaBoost), extreme gradient boosting (XGBoost) and gradient boosting machine (GBM) were developed. These models were assessed by the area under curve (AUC) of receiver operating characteristic on the testing set. The related risk factors and outcomes of pneumonia were also probed based on the chosen model.

results591 OLT patients were eventually included and 253 (42.81%) were diagnosed with postoperative pneumonia, which was associated with increased postoperative hospitalization and mortality (P < 0.05). Among the six ML models, XGBoost model performed best. The AUC of XGBoost model on the testing set was 0.734 (sensitivity: 52.6%; specificity: 77.5%). Pneumonia was notably associated with 14 items features: INR, HCT, PLT, ALB, ALT, FIB, WBC, PT, serum Na

conclusionOur study firstly demonstrated that the XGBoost model with 14 common variables might predict postoperative pneumonia in OLT patients.

Indexed as

Machine LearningAdultDeep LearningElectronic Health RecordsFemaleHumansLiver TransplantationMaleMiddle AgedPneumoniaPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsSupport Vector MachineTreatment OutcomeDeep learningDisease predictionEarly interventionExtreme gradient boostingLiver transplantationMachine learningML algorithmPostoperative pneumoniaPostoperative pulmonary complicationsRisk factors

Identifiers

PMID33789673
PMCPMC8011203

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.