Evidence map›Paper›PMID 33789598›Full record

ArticleBMC infectious diseases2021

Francisella tularensis human infections in a village of northwest Iran.

Saber Esmaeili, Mahdi Rohani, Ahmad Ghasemi, Mohammad Mehdi Gouya, Simin Khayatzadeh, Ahmad Mahmoudi, Hossein Ahangari Cohan, Anders Johansson, Max Maurin, Ehsan Mostafavi

Open access · goldAbstract read
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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  5. Virulence and genome analysis of three historicalFrontiers in cellular and infection microbiology · 2025
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  6. Article
  7. First molecular detection ofInternational journal for parasitology. Parasites and wildlife · 2024
    Article
  8. New microbes and new infections · 2023
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Saber Esmaeili *National Reference laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran.
Mahdi Rohani *National Reference laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran.
Ahmad GhasemiNational Reference laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran.
Mohammad Mehdi GouyaCenter for Communicable Disease Control, Ministry of Health and Medical Education, Tehran, Iran.
Simin KhayatzadehDepartment of Communicable Disease Control, Deputy of Health, Tabriz University of Medical Sciences, Tabriz, Iran.
Ahmad MahmoudiDepartment of Biology, Faculty of Science, Urmia University, Urmia, Iran.
Hossein Ahangari CohanNational Reference laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran.
Anders JohanssonDepartment of Clinical Microbiology and Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden.
Max MaurinUniversite Grenoble Alpes, CNRS, Grenoble INP, CHU Grenoble Alpes, TIMC-IMAG, 38000 Grenoble, Grenoble, France.
Ehsan MostafaviNational Reference laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran. mostafavi@pasteur.ac.ir.
Pasteur Institute of Iran · IRMinistry of Health and Medical Education · IRTabriz University of Medical Sciences · IRTranslational Innovation in Medicine and Complexity · FRUmeå University · SEUrmia University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent seroepidemiological studies have suggested that tularemia could be an endemic bacterial zoonosis in Iran.

methodsFrom January 2016 to June 2018, disease cases characterized by fever, cervical lymphadenopathy and ocular involvement were reported in Youzband Village of Kaleybar County, in the East Azerbaijan Province, northwestern Iran. Diagnostic tests included Francisella tularensis serology (including tube agglutination test and ELISA), PCR, and culture.

resultsAmong 11 examined case-patients, the tularemia tube agglutination test was positive in ten and borderline in one. PCR detected the F. tularensis ISFtu2 elements and fopA gene in one rodent and a spring water sample from the same geographic area.

conclusionsBased on the clinical manifestations of the disease suggesting an oropharyngeal form of tularemia, serology results in case patients, and F. tularensis detection in the local fauna and aquatic environment, the water supply of the village was the likely source of the tularemia outbreak. Intervention such as dredging and chlorination of the main water storage tank of the village and training of villagers and health care workers in preventive measures and treatment of the illness helped control the infection.

Indexed as

AdolescentAdultAgedAgglutination TestsAnimalsBacterial Outer Membrane ProteinsChildChild, PreschoolDNA, BacterialFemaleFrancisella tularensisFresh WaterHumansIranMaleMiceBacterial Outer Membrane ProteinsDNA, BacterialFopA protein, Francisella tularensisChlorinationFrancisella tularensisRodentTularemiaWater

Identifiers

PMID33789598
PMCPMC8010941
OpenAlexW3142207724

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.