Evidence map›Paper›PMID 33789551›Full record

ArticleBeneficial microbes2021

Gut microbial differences in breast and prostate cancer cases from two randomised controlled trials compared to matched cancer-free controls.

K S Smith, A D Frugé, W van der Pol, N E Caston, C D Morrow, W Demark-Wahnefried, T L Carson

2 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in Beneficial microbes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01886677 nacompletednot on this map

Exploring the Impact of Negative Energy Balance in Men With Prostate Cancer

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2012 to 2015Enrolled40ConditionsProstate CancerArmsImmediate diet and exercise intervention, Delayed diet and exercise intervention
NCT02224807 nacompletednot on this map

Exploring Effects of Weight Loss on Ductal Carcinoma In Situ

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2014 to 2018Enrolled32ConditionsDuctal Carcinoma In Situ, Breast CancerArmsActive Comparator: Progressive Resistance Training (PRT) and a healthy diet, Experimental: PRT and a healthy diet, plus weight loss
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Intratumoral Microbiome of Metastatic Pancreatic Ductal Adenocarcinoma.International journal of molecular sciences · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Microbial dysbiosis and inferred functional profiling reveals the potential role ofFrontiers in cellular and infection microbiology · 2026
    Article
  9. Review
  10. Specific microbiome patterns and their association with breast cancer: the intestinal microbiota as a potential biomarker and therapeutic strategy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
  11. Article
  12. Review
  13. Review
  14. Gut microbiome: a novel preventive and therapeutic target for prostatic disease.Frontiers in cellular and infection microbiology · 2024
    Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

K S SmithDepartment of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL 36849, USA.
A D FrugéDepartment of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL 36849, USA.
W van der PolUniversity of Alabama at Birmingham, Center for Clinical and Translational Science, Birmingham, AL 35233, USA.
N E CastonUniversity of Alabama at Birmingham, Division of Hematology and Oncology, Birmingham, AL 35233, USA.
C D MorrowUniversity of Alabama at Birmingham, Department of Cell, Developmental, and Integrative Biology, Birmingham, AL 35233, USA.
W Demark-WahnefriedUniversity of Alabama at Birmingham, Department of Nutrition Science, Birmingham, AL 35233, USA.
T L CarsonUniversity of Alabama at Birmingham, Department of Preventive Medicine, Birmingham, AL 35233, USA.
Auburn University · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Latesha Ellen Elopre · 1988 to 2026
$84.1M
Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2000 to 2026
$31.9M
UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
Cancer Prevention & Control Training ProgramR25CA047888 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEMARK-WAHNEFRIED, WENDY, MENESES, KAREN M · 1988 to 2016
$11.2M
UAB Center for Clinical and Translational Science (CCTS) UL1UL1TR000165 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2012 to 2013
$9.6M
UAB Skin Diseases Research CenterP30AR050948 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GRIZZLE, WILLIAM E. · 2004 to 2013
$5.5M
UAB Cancer Prevention and Control Training Program (T32)T32CA047888 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Ritu Aneja, Ellen Mary Lavoie Smith · 2018 to 2026
$3.2M
Exploring Effects of Weight Loss on Ductal Carcinoma In SituR21CA178359 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEMARK-WAHNEFRIED, WENDY · 2014 to 2015
$352k
Exploring the Impact of Negative Energy Balance in Men with Prostate CancerR21CA161263 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEMARK-WAHNEFRIED, WENDY · 2012 to 2013
$341k
NCATS NIH HHS UL1 TR000165NCATS NIH HHS UL1 TR001417NCI NIH HHS P30 CA013148NCI NIH HHS R21 CA161263NCI NIH HHS R21 CA178359NCI NIH HHS R25 CA047888NCI NIH HHS T32 CA047888NIAID NIH HHS P30 AI027767NIAMS NIH HHS P30 AR050948NIDDK NIH HHS P30 DK056336
6 · The paper itself

Abstract

Implicated in several chronic diseases, the gastrointestinal microbiome is hypothesised to influence carcinogenesis. We compared faecal microbiota of newly diagnosed treatment-naïve overweight and obese cancer patients and matched controls. Cases were enrolled in presurgical weight-loss trials for breast (NCT02224807) and prostate (NCT01886677) cancers and had a body mass index (BMI) ≥25 kg/m

Indexed as

Gastrointestinal MicrobiomeBreast NeoplasmsCase-Control StudiesFecesFemaleHumansMaleMiddle AgedObesityOverweightProstatic NeoplasmsRandomized Controlled Trials as Topicbeta-diversitycase-controlgut microbiotaoncology

Identifiers

PMID33789551
PMCPMC8328038
OpenAlexW3148278519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.