ArticleNature2021
A myeloid-stromal niche and gp130 rescue in NOD2-driven Crohn's disease.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
16.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 125 citations in OpenAlex.
- Trial
- A NOD2 to the endothelium for protective gut immunity.Nature immunology · 2026Article
- Single-cell RNA sequencing of terminal ileal biopsies identifies signatures of Crohn's disease pathogenesis.Nature genetics · 2026Article
- Estrogen impacts NOD2-dependent regulation of intestinal homeostasis.PLoS biology · 2026Article
- Fecal microbiota transplantation from healthy piglets ameliorates intestinal inflammation in mice by modulating recipient metabolism.BMC microbiology · 2026Article
- Bazedoxifene and Beyond: Identifying This SERM's Targets and Deciphering Its Molecular Mechanisms.Advances in pharmacological and pharmaceutical sciences · 2026Review
- Development and functional adaptation of intestinal macrophages across the lifespan.Clinical & translational immunology · 2026Review
- The role of theFrontiers in microbiology · 2026Review
- The gut-lung axis: pathological crosstalk and inter-organ communication in chronic obstructive pulmonary disease and inflammatory bowel disease.Frontiers in immunology · 2026Review
- PEGylated black-phosphorus nanosheet-alginate hydrogels enable local PRRX1 delivery to drive fibroblast reprogramming in intestinal fibrosis.Journal of nanobiotechnology · 2025Article
- Beyond inflammation: what drives the self-perpetuating cycle of fibrosis in IBD?Annals of medicine · 2025Review
- IL-26 from innate lymphoid cells regulates early-life gut epithelial homeostasis by shaping microbiota composition.The EMBO journal · 2025Article
- Tolerability and effect of inhibiting microfibrillar-associated protein 4 in small intestinal anastomotic healing.Scientific reports · 2025Article
- Article
- Progress in targeting the NLRP3 signaling pathway for inflammatory bowel disease (Review).Molecular medicine reports · 2025Review
- Gene-environment interactions shape the host-microbial interface in inflammatory bowel disease.Nature immunology · 2025Review
- TRIM22 governs tumorigenesis and protects against endometrial cancer-associated cachexia by inhibiting inflammatory response and adipose thermogenic activity.Cancer & metabolism · 2025Article
- Different fibroblast subtypes propel spatially defined ileal inflammation through TNFR1 signalling in murine ileitis.Nature communications · 2025Article
- Shared Genetics in Celiac Disease and Inflammatory Bowel Disease Specify a Greater Role for Intestinal Epithelial Cells.International journal of molecular sciences · 2025Review
- NOD2 and Crohn's Disease Clinical Practice: From Epidemiology to Diagnosis and Therapy, Rewired.Inflammatory bowel diseases · 2025Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Shikha NayarDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-8519-4569
Joshua K MorrisonDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-4174-6338
Mamta GiriThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kyle GettlerDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ling-Shiang ChuangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5054-1305
Laura A WalkerThe Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Huaibin M KoDepartment of Pathology, The Mount Sinai Hospital, New York, NY, USA.ORCID http://orcid.org/0000-0003-1062-2383
Ephraim KenigsbergDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-4107-3295
Subra KugathasanDepartment of Pediatric Gastroenterology, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-8686-4189
Miriam MeradThe Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-4481-7827
Jaime ChuDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Judy H ChoThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. judy.cho@mssm.edu.ORCID http://orcid.org/0000-0002-7959-0466
Icahn School of Medicine at Mount Sinai · USChild Health and Development Institute · USColumbia University Irving Medical Center · USEmory University · US
Funding
Yale University Inflammatory Bowel Disease Genetics Research CenterU01DK062422 · NIDDK · YALE UNIVERSITY · PI Ling-shiang Chuang · 2002 to 2026
$10.8MIntegrative Genomic Analyses of Macrophages in Crohns DiseaseR01DK106593 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHO, JUDY H. · 2016 to 2020
$3.8MIntestinal single cell analyses and population differences in innate immunity in Crohn's disease drive treatment response and clinical heterogeneity: towards Precision IBDR01DK123758 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHO, JUDY H. · 2020 to 2023
$2.9MMannose metabolism as a regulator of hepatic stellate cell activation and fibrosisR01DK121154 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHU, JAIME C · 2020 to 2024
$2.3MNIDDK NIH HHS R01 DK106593NIDDK NIH HHS R01 DK121154NIDDK NIH HHS R01 DK123758NIDDK NIH HHS U01 DK062422
Abstract
Crohn's disease is a chronic inflammatory intestinal disease that is frequently accompanied by aberrant healing and stricturing complications. Crosstalk between activated myeloid and stromal cells is critical in the pathogenicity of Crohn's disease
Indexed as
AllelesAnimalsCollagenCrohn DiseaseCytokine Receptor gp130Disease Models, AnimalFemaleFibroblastsHumansIleitisIndolesInterleukin-11Lipopolysaccharide ReceptorsMacrophagesMaleMyeloid CellsbazedoxifeneCollagenCytokine Receptor gp130IndolesInterleukin-11Lipopolysaccharide ReceptorsNOD2 protein, humanNOD2 protein, zebrafishNod2 Signaling Adaptor ProteinReceptor, Platelet-Derived Growth Factor alphaSTAT3 protein, humanSTAT3 Transcription FactorWT1 ProteinsZebrafish Proteins
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.