ArticleNeuroImage2021
Multimodal neurocognitive markers of frontal lobe epilepsy: Insights from ecological text processing.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Electrophysiological alterations during action semantic processing in Parkinson's disease.Neurobiology of aging · 2024Article
- Neurocognitive correlates of semantic memory navigation in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Impaired social concept processing in persons with autistic-like traits.Scientific reports · 2023Article
- Social concepts and the cerebellum: behavioural and functional connectivity signatures in cerebellar ataxic patients.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- On the replicability of action-verb deficits in Parkinson's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Ecological Meanings: A Consensus Paper on Individual Differences and Contextual Influences in Embodied Language.Journal of cognition · 2023Article
- Multidimensional inhibitory signatures of sentential negation in behavioral variant frontotemporal dementia.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Detecting Parkinson's disease and its cognitive phenotypes via automated semantic analyses of action stories.NPJ Parkinson's disease · 2022Article
- Multimodal Neurocognitive Markers of Naturalistic Discourse Typify Diverse Neurodegenerative Diseases.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- An action-concept processing advantage in a patient with a double motor cortex.Brain and cognition · 2022Article
- The Bilingual Lexicon, Back and Forth: Electrophysiological Signatures of Translation Asymmetry.Neuroscience · 2022Article
- Automated text-level semantic markers of Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Structural and functional motor-network disruptions predict selective action-concept deficits: Evidence from frontal lobe epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Multimodal neurocognitive markers of frontal lobe epilepsy: Insights from ecological text processing.NeuroImage · 2021Article
- The Neural Blending of Words and Movement: Event-Related Potential Signatures of Semantic and Action Processes during Motor-Language Coupling.Journal of cognitive neuroscience · 2021Article
- Rekindling Action Language: A Neuromodulatory Study on Parkinson's Disease Patients.Brain sciences · 2021Article
- Discourse-Level Information Recall in Early and Late Bilinguals: Evidence From Single-Language and Cross-Linguistic Tasks.Frontiers in psychology · 2021Article
- Predicting and Characterizing Neurodegenerative Subtypes with Multimodal Neurocognitive Signatures of Social and Cognitive Processes.Journal of Alzheimer's disease : JAD · 2021Article
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11 authors.
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Abstract
The pressing call to detect sensitive cognitive markers of frontal lobe epilepsy (FLE) remains poorly addressed. Standard frameworks prove nosologically unspecific (as they reveal deficits that also emerge across other epilepsy subtypes), possess low ecological validity, and are rarely supported by multimodal neuroimaging assessments. To bridge these gaps, we examined naturalistic action and non-action text comprehension, combined with structural and functional connectivity measures, in 19 FLE patients, 19 healthy controls, and 20 posterior cortex epilepsy (PCE) patients. Our analyses integrated inferential statistics and data-driven machine-learning classifiers. FLE patients were selectively and specifically impaired in action comprehension, irrespective of their neuropsychological profile. These deficits selectively and specifically correlated with (a) reduced integrity of the anterior thalamic radiation, a subcortical structure underlying motoric and action-language processing as well as epileptic seizure spread in this subtype; and (b) hypoconnectivity between the primary motor cortex and the left-parietal/supramarginal regions, two putative substrates of action-language comprehension. Moreover, machine-learning classifiers based on the above neurocognitive measures yielded 75% accuracy rates in discriminating individual FLE patients from both controls and PCE patients. Briefly, action-text assessments, combined with structural and functional connectivity measures, seem to capture ecological cognitive deficits that are specific to FLE, opening new avenues for discriminatory characterizations among epilepsy types.
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