ArticleCell reports2021
UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction.
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Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- The function of mRNA quality control in aging and age-related diseases.The Journal of biological chemistry · 2026Review
- Article
- Beyond Antioxidants: The Emerging Role of Nrf2 Activation in Amyotrophic Lateral Sclerosis (ALS).International journal of molecular sciences · 2025Review
- Rewired m6A of promoter antisense RNAs in Alzheimer's disease regulates neuronal genes in 3D nucleome.Nature communications · 2025Article
- Targeting GeneInternational journal of molecular sciences · 2025Review
- Context-dependent Interactors Regulate TDP-43 Dysfunction in ALS/FTLD.bioRxiv : the preprint server for biology · 2025Article
- RuvBL1/2 reduce toxic dipeptide repeat protein burden in multiple models of C9orf72-ALS/FTD.Life science alliance · 2025Article
- RNA dysregulation in neurodegenerative diseases.The EMBO journal · 2025Review
- TDP43 autoregulation gives rise to dominant negative isoforms that are tightly controlled by transcriptional and post-translational mechanisms.Cell reports · 2025Article
- Decoding Nucleotide Repeat Expansion Diseases: Novel Insights fromInternational journal of molecular sciences · 2024Review
- [Late-onset hereditary hearing loss caused byLin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Article
- TDP43 autoregulation gives rise to shortened isoforms that are tightly controlled by both transcriptional and post-translational mechanisms.bioRxiv : the preprint server for biology · 2024Article
- Invertebrate genetic models of amyotrophic lateral sclerosis.Frontiers in molecular neuroscience · 2024Review
- YTHDF2 facilitates aggresome formation via UPF1 in an mNature communications · 2023Article
- Dexmedetomidine Promoted HSPB8 Expression via Inhibiting the lncRNA SNHG14/UPF1 Axis to Inhibit Apoptosis of Nerve Cells in AD : The Role of Dexmedetomidine in AD.Neurotoxicity research · 2023Article
- Globally reduced NNature neuroscience · 2023Article
- Advances in the Structure of GGGGCC Repeat RNA Sequence and Its Interaction with Small Molecules and Protein Partners.Molecules (Basel, Switzerland) · 2023Review
- UPF1-From mRNA Degradation to Human Disorders.Cells · 2023Review
- RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia.Molecular cell · 2023Article
- RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration.Frontiers in genetics · 2022Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Benjamin L ZaepfelBiochemistry, Cellular and Molecular Biology Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Molecular Biology and Genetics Department, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Zhe ZhangDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Kirstin MauldingBrain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Cellular and Molecular Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Alyssa N CoyneBrain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Weiwei ChengDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Lindsey R HayesDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Thomas E LloydBrain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: tlloyd4@jhmi.edu.
Shuying SunDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: shuying.sun@jhmi.edu.
Jeffrey D RothsteinBrain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: jrothstein@jhmi.edu.
Johns Hopkins University · US
Funding
BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1MProject 3: Neuropathology of the multi-proteinopathy of c9FTD/ALS.P01NS084974 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2014 to 2024
$17.6MNucleocytoplasmic transport and nuclear pore disruption in ALS/FTDR01NS094239 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LLOYD, THOMAS E., ROTHSTEIN, JEFFREY D · 2016 to 2020
$3.4MALS/FTD mutant C9orf72-induced genetic and nuclear pathology in iPS cell modelsR01NS085207 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ROTHSTEIN, JEFFREY D, SATTLER, RITA · 2013 to 2017
$1.8MMolecular mechanism of dipeptide repeat protein production from hexanucleotide repeats in C9ORF72-related ALS and FTDR01NS107347 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SUN, SHUYING · 2018 to 2022
$1.8MFG-nucleoporins and nuclear transport disruption in C9ORF72-ALS/FTDK08NS104273 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HAYES, LINDSEY RENAE · 2017 to 2021
$999kNIGMS NIH HHS T32 GM007445NINDS NIH HHS K08 NS104273NINDS NIH HHS P01 NS084974NINDS NIH HHS R01 NS085207NINDS NIH HHS R01 NS094239NINDS NIH HHS R01 NS107347
Abstract
Multiple cellular pathways have been suggested to be altered by the C9orf72 GGGGCC (G
Indexed as
Amyotrophic Lateral SclerosisAnimalsC9orf72 ProteinDisease Models, AnimalDNA Repeat ExpansionDrosophila melanogasterHEK293 CellsHeLa CellsHumansInduced Pluripotent Stem CellsMotor CortexNerve DegenerationNeurotoxicity SyndromesNonsense Mediated mRNA DecayPhenotypePostmortem ChangesC9orf72 ProteinRNARNA HelicasesTrans-ActivatorsUPF1 protein, humanamyotrophic lateral sclerosisC9ORF72frontotemporal dementiainduced pluripotent cellsneuronsneurotoxicitynonsense-mediated decayUPF1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.