ArticleNeuron2021
Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model.
Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56 citing papers in PubMed, 131 citations in OpenAlex.
- Preparatory encoding of intended movement in the human motor cortex and implications for brain-computer interfaces.Current biology : CB · 2026Article
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- Pretraining of Embodied Recurrent Networks Bridges the Gap Between Artificial and Cortical Neural Activities.Biomimetics (Basel, Switzerland) · 2026Article
- Distinct sensorimotor encoding in tuft dendrites and somata associated with action, correction, and learning.bioRxiv : the preprint server for biology · 2026Article
- Sparse component analysis: A method that uncovers separable computations within neural population activity.Neuron · 2026Article
- Parkinsonism disrupts the population-level organization of cortical dynamics.bioRxiv : the preprint server for biology · 2026Article
- Metabotropic glutamate receptor 5 in the anterior cingulate cortex predicts individual differences in motor impulsivity but not in risky decision-making.Translational psychiatry · 2026Article
- Interpreting the kinematic theory of rapid human movement as an optimal control theory.Frontiers in human neuroscience · 2026Article
- Striatal ensembles specify and control granular forelimb actions.bioRxiv : the preprint server for biology · 2025Article
- Embodied sensorimotor control: computational modeling of the neural control of movement.ArXiv · 2025Article
- Frontal and parietal planning signals encode adapted motor commands when learning to control a brain-computer interface.PLoS biology · 2025Article
- Basal ganglia: an amplifier for preparatory activity in motor control.Biological cybernetics · 2025Article
- Neural geometry from mixed sensorimotor selectivity for predictive sensorimotor control.eLife · 2025Article
- Continuous sensorimotor transformation enhances robustness of neural dynamics to perturbation in macaque motor cortex.Nature communications · 2025Article
- Mediodorsal thalamus regulates task uncertainty to enable cognitive flexibility.Nature communications · 2025Article
- Cerebellar output shapes cortical preparatory activity during motor adaptation.Nature communications · 2025Article
- Cerebellar output shapes cortical preparatory activity during motor adaptation.bioRxiv : the preprint server for biology · 2025Article
- Dynamical constraints on neural population activity.Nature neuroscience · 2025Article
- A theory of brain-computer interface learning via low-dimensional control.bioRxiv : the preprint server for biology · 2025Article
- Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Across a range of motor and cognitive tasks, cortical activity can be accurately described by low-dimensional dynamics unfolding from specific initial conditions on every trial. These "preparatory states" largely determine the subsequent evolution of both neural activity and behavior, and their importance raises questions regarding how they are, or ought to be, set. Here, we formulate motor preparation as optimal anticipatory control of future movements and show that the solution requires a form of internal feedback control of cortical circuit dynamics. In contrast to a simple feedforward strategy, feedback control enables fast movement preparation by selectively controlling the cortical state in the small subspace that matters for the upcoming movement. Feedback but not feedforward control explains the orthogonality between preparatory and movement activity observed in reaching monkeys. We propose a circuit model in which optimal preparatory control is implemented as a thalamo-cortical loop gated by the basal ganglia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.