ArticleEndocrinology and metabolism (Seoul, Korea)2021
Diagnostic Accuracy of Computed Tomography in Predicting Primary Aldosteronism Subtype According to Age.
Article in Endocrinology and metabolism (Seoul, Korea), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adrenal Vein Sampling for Primary Aldosteronism: Recommendations From the Australian and New Zealand Working Group.Clinical endocrinology · 2025Guideline
- A Ten Year Overview of Adrenal Vein Sampling in Croatia: Insights and Outcomes.Clinical endocrinology · 2026Article
- CT-based body composition enhances prognostic performance of PASO score for surgical outcome in primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Assessment, External Verification and Modification of Models in Diagnosing Primary Aldosteronism Subtypes.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Optimising patient selection for adrenal vein sampling in primary aldosteronism: role of biochemical markers and scoring systems.Endocrine · 2026Article
- [Modern capabilities of contrast-enhanced computed tomography in the diagnosis of adrenal adenomas].Problemy endokrinologii · 2026Article
- Identifying unilateral aldosterone-producing adenomas using published algorithms and imaging: a systematic review and meta-analysis.Endocrine connections · 2025Article
- Case selection of adrenal vein sampling in young patients with primary aldosteronism: a retrospective analysis of imaging and AVS concordance, and histopathological outcomes.Endocrine connections · 2025Article
- Evaluation of Predictive Risk Factors of Persistent Hypertension in Hyperaldosteronism After Surgery.International journal of endocrinology and metabolism · 2025Article
- Bridging Global and Local Perspectives on Primary Aldosteronism.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- [Theranostics · 2024Article
- 2023 Korean Endocrine Society Consensus Guidelines for the Diagnosis and Management of Primary Aldosteronism.Endocrinology and metabolism (Seoul, Korea) · 2023Article
- Accuracy of Gallium-68 Pentixafor Positron Emission Tomography-Computed Tomography for Subtyping Diagnosis of Primary Aldosteronism.JAMA network open · 2023Article
- Validation of Existing Clinical Prediction Tools for Primary Aldosteronism Subtyping.Diagnostics (Basel, Switzerland) · 2022Article
- Diagnostic Accuracy of Computed Tomography in Predicting Primary Aldosteronism Subtype According to Age (Endocrinol Metab 2021;36:401-12, Seung Hun Lee et al.).Endocrinology and metabolism (Seoul, Korea) · 2021Article
- Diagnostic Accuracy of Computed Tomography in Predicting Primary Aldosteronism Subtype According to Age (Endocrinol Metab 2021;36:401-12, Seung Hun Lee et al.).Endocrinology and metabolism (Seoul, Korea) · 2021Article
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Abstract
backgroundGuidelines by the Endocrine Society Guideline on bypassing adrenal vein sampling (AVS) in patients <35 years old with marked primary aldosteronism (PA) (hypokalemia and elevated plasma aldosterone concentration [PAC]) and a unilateral lesion on computed tomography (CT) are based on limited number of studies. We aimed to determine the accuracy of CT in PA patients according to age.
methodsIn this retrospective study, we investigated the concordance between CT and AVS in 466 PA patients from two tertiary centers who successfully underwent AVS.
resultsCT had an overall accuracy of 64.4% (300/466). In the group with unilateral lesion, patients with hypokalemia had higher concordance than those without hypokalemia (85.0% vs. 43.6%, P<0.001). In the group with marked PA (hypokalemia and PAC >15.9 ng/dL) and unilateral lesion, accuracy of CT was 84.6% (11/13) in patients aged <35 years; 100.0% (20/20), aged 35 to 39 years; 89.4% (59/66), aged 40 to 49 years; and 79.8% (79/99), aged ≥50 years. Cut-off age and PAC for concordance was <50 years and >29.6 ng/dL, respectively. The significant difference in accuracy of CT in 198 patients with marked PA and a unilateral lesion between the <50-year age group and ≥50-year age group (90.9% vs. 79.8%, P=0.044) disappeared in 139 of 198 patients with PAC > 30.0 ng/dL (91.9% vs. 87.7%, P=0.590).
conclusionPatients with hypokalemia, PAC >30.0 ng/dL, and unilateral lesion were at high risk of unilateral PA regardless of age.
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