ArticlePloS one2021
A p53-like transcription factor, BbTFO1, contributes to virulence and oxidative and thermal stress tolerances in the insect pathogenic fungus, Beauveria bassiana.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Temperature-associated metabolic responses of Aspergillus cristatus revealed by untargeted LC-MS metabolomics.World journal of microbiology & biotechnology · 2026Article
- Transcription Factors in Biocontrol Fungi.Journal of fungi (Basel, Switzerland) · 2025Review
- Combined effects of entomopathogenic fungi, plant extracts, and biorational insecticides on Morocain endemic bush cricketFrontiers in microbiology · 2025Article
- Current developments in the resistance, quality, and production of entomopathogenic fungi.World journal of microbiology & biotechnology · 2022Review
- BbWor1, a Regulator of Morphological Transition, Is Involved in Conidium-Hypha Switching, Blastospore Propagation, and Virulence in Beauveria bassiana.Microbiology spectrum · 2021Article
- Transcriptome Analysis of the Japanese Pine Sawyer Beetle,Journal of fungi (Basel, Switzerland) · 2021Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The p53-like transcription factor (TF) NDT80 plays a vital role in the regulation of pathogenic mechanisms and meiosis in certain fungi. However, the effects of NDT80 on entomopathogenic fungi are still unknown. In this paper, the NDT80 orthologue BbTFO1 was examined in Beauveria bassiana, a filamentous entomopathogenic fungus, to explore the role of an NDT80-like protein for fungal pest control potential. Disruption of BbTFO1 resulted in impaired resistance to oxidative stress (OS) in a growth assay under OS and a 50% minimum inhibitory concentration experiment. Intriguingly, the oxidation resistance changes were accompanied by transcriptional repression of the two key antioxidant enzyme genes cat2 and cat5. ΔBbTFO1 also displayed defective conidial germination, virulence and heat resistance. The specific supplementation of BbTFO1 reversed these phenotypic changes. As revealed by this work, BbTFO1 can affect the transcription of catalase genes and play vital roles in the maintenance of phenotypes associated with the biological control ability of B. bassiana.
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