Evidence map›Paper›PMID 33788864›Full record

ArticlePLoS neglected tropical diseases2021

Poverty, sanitation, and Leptospira transmission pathways in residents from four Brazilian slums.

Hussein Khalil, Roberta Santana, Daiana de Oliveira, Fabiana Palma, Ricardo Lustosa, Max T Eyre, Ticiana Carvalho-Pereira, Mitermayer G Reis, Albert I Ko, Peter J Diggle and 3 more

Abstract read
In one paragraph

Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  16. A Scoping Review of Antimicrobial Therapy inAnimals : an open access journal from MDPI · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Leptospirosis.Nature reviews. Disease primers · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hussein KhalilInstitute of Collective Health, Federal University of Bahia, Salvador, Brazil.ORCID 0000-0001-9982-6387
Roberta SantanaInstitute of Collective Health, Federal University of Bahia, Salvador, Brazil.
Daiana de OliveiraInstitute of Collective Health, Federal University of Bahia, Salvador, Brazil.ORCID 0000-0003-0581-3433
Fabiana PalmaInstitute of Collective Health, Federal University of Bahia, Salvador, Brazil.ORCID 0000-0002-7345-4914
Ricardo LustosaInstitute of Collective Health, Federal University of Bahia, Salvador, Brazil.ORCID 0000-0001-5033-690X
Max T EyreCentre for Health Informatics, Computing, and Statistics, Lancaster University Medical School, Lancaster, United Kingdom.ORCID 0000-0001-9847-8632
Ticiana Carvalho-PereiraInstitute of Collective Health, Federal University of Bahia, Salvador, Brazil.ORCID 0000-0003-2370-2198
Mitermayer G ReisInstituto Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde, Salvador, Brazil.
Albert I KoInstituto Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde, Salvador, Brazil.ORCID 0000-0001-9023-2339
Peter J DiggleCentre for Health Informatics, Computing, and Statistics, Lancaster University Medical School, Lancaster, United Kingdom.ORCID 0000-0003-3521-5020
Yeimi Alzate LopezInstitute of Collective Health, Federal University of Bahia, Salvador, Brazil.ORCID 0000-0001-6243-9367
Mike BegonDepartment of Evolution, Ecology and Behaviour, The University of Liverpool, United Kingdom.ORCID 0000-0003-1715-5327
Federico CostaInstitute of Collective Health, Federal University of Bahia, Salvador, Brazil.ORCID 0000-0001-6951-2336

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Ecoepidemiology of leptospirosis in the urban slums of BrazilR01TW009504 · FIC · YALE UNIVERSITY · PI BEGON, MICHAEL, CHILDS, JAMES EMORY · 2012 to 2016
$2.2M
FIC NIH HHS R01 TW009504Medical Research Council MR/P024084/1NCATS NIH HHS UL1 TR001863Wellcome TrustWellcome Trust 102330/Z/13/Z
6 · The paper itself

Abstract

Residents of urban slums suffer from a high burden of zoonotic diseases due to individual, socioeconomic, and environmental factors. We conducted a cross-sectional sero-survey in four urban slums in Salvador, Brazil, to characterize how poverty and sanitation contribute to the transmission of rat-borne leptospirosis. Sero-prevalence in the 1,318 participants ranged between 10.0 and 13.3%. We found that contact with environmental sources of contamination, rather than presence of rat reservoirs, is what leads to higher risk for residents living in areas with inadequate sanitation. Further, poorer residents may be exposed away from the household, and ongoing governmental interventions were not associated with lower transmission risk. Residents at higher risk were aware of their vulnerability, and their efforts improved the physical environment near their household, but did not reduce their infection chances. This study highlights the importance of understanding the socioeconomic and environmental determinants of risk, which ought to guide intervention efforts.

Indexed as

PovertyPoverty AreasSanitationAdultBrazilCross-Sectional StudiesFemaleHumansLeptospirosisMaleMiddle AgedSocial Class

Identifiers

PMID33788864
PMCPMC8041187

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.