Evidence map›Paper›PMID 33788578›Full record

ReviewMolecular biology of the cell2021

Imaging methods in mechanosensing: a historical perspective and visions for the future.

Kirill Lavrenyuk, Daniel Conway, Kris Noel Dahl

Abstract readReview
In one paragraph

Review in Molecular biology of the cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Principles and regulation of mechanosensing.Journal of cell science · 2024
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. The Elephant in the Cell: Nuclear Mechanics and Mechanobiology.Journal of biomechanical engineering · 2022
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kirill LavrenyukCarnegie Mellon University, College of Engineering, Pittsburgh, PA 15213.
Daniel ConwayVirginia Commonwealth University, College of Engineering, Richmond, VA 23284.
Kris Noel DahlCarnegie Mellon University, College of Engineering, Pittsburgh, PA 15213.

Funding

Cell junction and nuclear forces as mediators of epithelial cell homeostasisR35GM119617 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI Daniel E Conway · 2016 to 2026
$4.5M
Training in the Molecular Biophysics and Structural BiologyT32GM088119 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HINCK, ANDREW P · 2011 to 2020
$1.6M
NIGMS NIH HHS R35 GM119617NIGMS NIH HHS T32 GM088119
6 · The paper itself

Abstract

Over the past three decades, as mechanobiology has become a distinct area of study, researchers have developed novel imaging tools to discover the pathways of biomechanical signaling. Early work with substrate engineering and particle tracking demonstrated the importance of cell-extracellular matrix interactions on the cell cycle as well as the mechanical flux of the intracellular environment. Most recently, tension sensor approaches allowed directly measuring tension in cell-cell and cell-substrate interactions. We retrospectively analyze how these various optical techniques progressed the field and suggest our vision forward for a unified theory of cell mechanics, mapping cellular mechanosensing, and novel biomedical applications for mechanobiology.

Indexed as

AnimalsBiomechanical PhenomenaBiophysicsCell DifferentiationExtracellular MatrixHumansMechanotransduction, CellularOptical ImagingSignal Transduction

Identifiers

PMID33788578
PMCPMC8108522

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.