Evidence map›Paper›PMID 33788184›Full record

ArticleAdvances in experimental medicine and biology2021

Potential Role of Mast Cells in Regulating Corticosteroid Insensitivity in Severe Asthma.

Abdulrahman Alzahrani, Aamir Hussain, Fahad Alhadian, Jameel Hakeem, Sana Douaoui, Omar Tliba, Peter Bradding, Yassine Amrani

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Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
5.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Abdulrahman AlzahraniDepartment of Infection, Immunity and Inflammation, Clinical Sciences, University of Leicester, Leicester, UK.
Aamir HussainDepartment of Infection, Immunity and Inflammation, Clinical Sciences, University of Leicester, Leicester, UK.
Fahad AlhadianDepartment of Infection, Immunity and Inflammation, Clinical Sciences, University of Leicester, Leicester, UK.
Jameel HakeemDepartment of Infection, Immunity and Inflammation, Clinical Sciences, University of Leicester, Leicester, UK.
Sana DouaouiDepartment of Infection, Immunity and Inflammation, Clinical Sciences, University of Leicester, Leicester, UK.
Omar TlibaDepartment of Infection, Immunity and Inflammation, Clinical Sciences, University of Leicester, Leicester, UK.
Peter BraddingDepartment of Infection, Immunity and Inflammation, Clinical Sciences, University of Leicester, Leicester, UK.
Yassine AmraniDepartment of Respiratory Sciences, University of Leicester, Leicester, UK. ya26@le.ac.uk.
University of Leicester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms driving corticosteroid insensitivity in asthma are still unclear although evidence points toward a potential role of lung mast cells. Indeed, a number of in vitro studies using various cell types showed that different mediators produced by activated mast cells, including cytokines, have the capacity to interfere with the therapeutic action of corticosteroids. In patients with severe allergic refractory asthma, the anti-IgE monoclonal antibody (mAb), Omalizumab, has been shown to be associated with a marked reduction in inhaled and systemic use of corticosteroids, further suggesting a key role of mast cells in the poor response of patients to these drugs. The present chapter will discuss the possible underlying mechanisms by which mast cells could contribute to reducing corticosteroid sensitivity seen in patients with severe asthma.

Indexed as

AsthmaMast CellsAdrenal Cortex HormonesAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedHumansAdrenal Cortex HormonesAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAirway inflammationAirway smooth muscleAlarminsCytokinesGrowth factorsIgEMast cellsReceptor

Identifiers

PMID33788184
OpenAlexW3148634359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.