Evidence map›Paper›PMID 33788155›Full record

ArticleLa Radiologia medica2021

The evolution of bone marrow signal changes at the skull base in nasopharyngeal carcinoma patients treated with radiation therapy.

Safak Parlak, Gozde Yazici, Anil Dolgun, Burce Ozgen

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Article in La Radiologia medica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Safak ParlakDepartment of Radiology, Faculty of Medicine, Hacettepe University, Sıhhiye/Ankara, Turkey. parlaksafak@gmail.com.ORCID http://orcid.org/0000-0002-6028-4653
Gozde YaziciDepartment of Radiation Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Anil DolgunDepartment of Mathematical Science, RMIT University, Melbourne, Australia.
Burce OzgenDepartment of Radiology, University of Illinois at Chicago, Chicago, IL, USA.
Hacettepe University · TRAustralian Mathematical Sciences Institute · AUUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClival infiltration is frequently seen in nasopharyngeal carcinoma (NPC) and the resultant bone marrow signal changes (BMSC) can persist even after complete tumor response to the radiation therapy (RT). The differentiation of those residual BMSC from recurrent/persistent disease may be challenging. We performed serial analysis of the clival BMSC after RT, to define an expected temporal evolution of those signal changes during the follow-up. MATERIALS AND

methodsSerial MRI studies of 50 NPC patients (with or without initial clival infiltration) who had undergone RT were retrospectively examined. Abnormal clival BMSC and contrast enhancement (CE) were evaluated on each follow-up scan. Duration of BMSC/CE was correlated with the degree of baseline clival involvement (BCID), RT dose, and primary mass volume (PMV).

resultsClival BMSC persisted without any evidence of recurrence, for a mean of 66.5 (max. 137) months (with accompanying CE for up to 125 months) in 26 patients with clival infiltration at diagnosis. Duration of BMSC and CE showed statistical correlations with PMW (p < 0.05), but not with RT dose or BCID. The rate of recurrence in clivus was 14%. New clival lesions that occurred within the first 12 months after RT (in six patients) did not develop recurrence suggesting radiation osteitis (12%).

conclusionAfter RT, residual clival medullary signal change/enhancement is seen in most NPC patients and can persist even years without recurrence.

Indexed as

AdolescentAdultAgedBone MarrowFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedNasopharyngeal CarcinomaNasopharyngeal NeoplasmsRetrospective StudiesYoung AdultClivusMagnetic resonance imagingNasopharyngeal carcinomaRadiation therapySkull base

Identifiers

PMID33788155
OpenAlexW3139859728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.