Evidence map›Paper›PMID 33788111›Full record

ArticleBulletin of experimental biology and medicine2021

Expression of Genes Encoding Nuclear Factors PPARγ, LXRβ, and RORα in Epicardial and Subcutaneous Adipose Tissues in Patients with Coronary Heart Disease.

A A Panteleeva, N D Razgildina, I A Pobozheva, E A Polyakova, K V Dracheva, O D Belyaeva, O A Berkovich, E I Baranova, S N Pchelina, V V Miroshnikova

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Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

A A PanteleevaB. P. Konstantinov St. Petersburg Nuclear Physics Institute, National Research Centre Kurchatov Institute, Gatchina, Russia. aleksandrapanteleeva@gmail.com.
N D RazgildinaB. P. Konstantinov St. Petersburg Nuclear Physics Institute, National Research Centre Kurchatov Institute, Gatchina, Russia.
I A PobozhevaB. P. Konstantinov St. Petersburg Nuclear Physics Institute, National Research Centre Kurchatov Institute, Gatchina, Russia.
E A PolyakovaI. P. Pavlov First St. Petersburg State Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
K V DrachevaB. P. Konstantinov St. Petersburg Nuclear Physics Institute, National Research Centre Kurchatov Institute, Gatchina, Russia.
O D BelyaevaI. P. Pavlov First St. Petersburg State Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
O A BerkovichI. P. Pavlov First St. Petersburg State Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
E I BaranovaI. P. Pavlov First St. Petersburg State Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
S N PchelinaB. P. Konstantinov St. Petersburg Nuclear Physics Institute, National Research Centre Kurchatov Institute, Gatchina, Russia.
V V MiroshnikovaB. P. Konstantinov St. Petersburg Nuclear Physics Institute, National Research Centre Kurchatov Institute, Gatchina, Russia.
First Pavlov State Medical University of St. Petersburg · RUKurchatov Institute · RUPetersburg Nuclear Physics Institute · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nuclear factors PPARγ, RORα, and LXRβ are involved in transcriptional control of adipogenesis and implicated in glucose and lipid metabolism. In adipose tissues, they regulate inflammation. This study focuses on expression of the PPARG, RORA, and LXRβ (NR1H2) genes in epicardial and subcutaneous adipose tissues in patients with coronary heart disease as well as with concomitant abdominal obesity. In patients with coronary heart disease and abdominal obesity, PPARG mRNA level in subcutaneous adipose tissue was reduced in comparison with control group. In patients with total coronary occlusions, LXRβ mRNA level in epicardial adipose tissue was reduced, and it positively correlated with plasma HDL cholesterol. Thus, in cases of concomitant abdominal obesity and chronic total coronary occlusions, coronary heart disease is characterized by down-regulated expression of the genes of various transcriptional adipogenesis-regulating factors in adipose tissue.

Indexed as

Adipose TissueAgedCoronary Artery DiseaseFemaleHumansLipid MetabolismLiver X ReceptorsMaleMiddle AgedNuclear Receptor Subfamily 1, Group F, Member 1PPAR gammaRNA, MessengerSubcutaneous FatLiver X ReceptorsNuclear Receptor Subfamily 1, Group F, Member 1PPAR gammaRNA, MessengerRORA protein, humanadipose tissuecoronary heart diseasenuclear factors

Identifiers

PMID33788111
OpenAlexW3097833016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.