Evidence map›Paper›PMID 33788045›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2021

Metabolomics analysis of serum in pediatric nephrotic syndrome based on targeted and non-targeted platforms.

Jing Guo, Jinhui Zhao, Rui Liu, Jiaying Yu, Mingjia Zhang, Hanming Wang, Liyan Liu

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Article in Metabolomics : Official journal of the Metabolomic Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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6citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Metabolomics Profiling of Nephrotic Syndrome towards Biomarker Discovery.International journal of molecular sciences · 2022
    Article
  6. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Jing GuoDepartment of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150086, People's Republic of China.
Jinhui ZhaoDepartment of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150086, People's Republic of China.
Rui LiuThe Department of Clinical Nutrition, Southern University of Science and Technology Hospital, Shenzhen, People's Republic of China.
Jiaying YuDepartment of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150086, People's Republic of China.
Mingjia ZhangDepartment of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150086, People's Republic of China.
Hanming WangDepartment of Infectious Diseases, Harbin Children's Hospital, 57 Youyi Road, Daoli District, Harbin, People's Republic of China.
Liyan LiuDepartment of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150086, People's Republic of China. yanziliu2100@163.com.ORCID http://orcid.org/0000-0001-6766-9508

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsNephrotic syndrome (NS) is a common pediatric urinary system disease. The aim in this work was to investigate the changes in pediatric NS-related metabolites through serum metabolomics, and explore the new potential metabolites and differential metabolic pathways.

methodsSerum samples from 40 pediatric patients with nephrotic syndrome and 40 healthy controls were collected. The targeted and non-targeted metabolomics analyses were performed to determine the metabolic changes in pediatric NS. Based on multivariate statistical analysis and the regression model, the serum potential metabolites were screened and different metabolic pathways were explored.

results39 differential metabolites in pediatric NS were obtained based on the metabolomics analysis. 12 differential metabolites (serine, C18: 2 (EFA), C18: 2 (FFA), Isonuatigenin 3- [rhamnosyl- (1- > 2) -glucoside], C18: 4 (EFA), C18: 4 (FFA), caprylic acid, citric acid, methylmalonic acid, caproic acid, canavalioside and uroporphyrin were identified to establish the diagnostic model for pediatric NS. Five metabolic pathways including TCA cycle, amino acid metabolism, bile acid biosynthesis, linoleate metabolism and glyoxylate and dicarboxylate metabolism were the key differential metabolic pathways.

conclusionThese data elucidated the metabolic alterations associated with pediatric NS and suggested a new diagnosis model for monitoring pediatric NS. The current study provides the useful information to bridge the gaps in our understanding of the metabolic alterations associated with pediatric NS and might facilitate the characterization of pediatric NS patients by performing serum metabolomics.

Indexed as

Amino AcidsBiogenic AminesBiomarkersCaprylatesChildChild, PreschoolFatty AcidsFemaleHumansInfantMaleMetabolic Networks and PathwaysMetabolomicsMultivariate AnalysisNephrotic SyndromeAmino AcidsBiogenic AminesBiomarkersCaprylatesFatty Acidsoctanoic acidDifferent metabolitesMetabolomicsPathway analysisPediatric nephrotic syndrome

Identifiers

PMID33788045

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.