ArticleHernia : the journal of hernias and abdominal wall surgery2022
Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen.
Article in Hernia : the journal of hernias and abdominal wall surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Autoimmunity and hernia mesh: fact or fiction?Hernia : the journal of hernias and abdominal wall surgery · 2023Pooled it
- Cyanoacrylate glue reactions: A systematic review, cases, and proposed mechanisms.Journal of vascular surgery. Venous and lymphatic disorders · 2023Pooled it
- Toward precision hernia surgery: integrating biomarkers, genomics, quantitative imaging, and artificial intelligence in abdominal wall repair.Hernia : the journal of hernias and abdominal wall surgery · 2026Review
- Reply to 'Polypropylene mesh degradation and systemic disease: biological plausibility is not clinical evidence'.Nature reviews. Urology · 2026Article
- Biomaterial physicochemical properties govern immune activation and bone regeneration: a titanium-focused design-oriented osteoimmunological framework.Frontiers in immunology · 2026Review
- The impact of steroid-impregnated polypropylene mesh on foreign body reaction in an experimental rat study.Acta cirurgica brasileira · 2026Article
- Distinct impacts of aging on the immune responses to extracellular matrix-based versus synthetic biomaterials.Biomaterials · 2025Article
- Crosstalk between T cells and fibroblasts in biomaterial-mediated fibrosis.Matrix biology plus · 2025Review
- Polypropylene surgical mesh induces lipid oxidation in a nonhuman primate model.Acta biomaterialia · 2025Article
- STING agonist-conjugated metal-organic framework induces artificial leukocytoid structures and immune hotspots for systemic antitumor responses.National science review · 2024Article
- Techniques for navigating postsurgical adhesions: Insights into mechanisms and future directions.Bioengineering & translational medicine · 2023Review
- Temporal trends in microplastic accumulation in placentas from pregnancies in Hawai'i.Environment international · 2023Article
- Preparation and Biocompatibility Study of Contrast-Enhanced Hernia Mesh Material.Tissue engineering and regenerative medicine · 2022Article
- Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity.Biomedical materials (Bristol, England) · 2022Review
- Quantitative Characterization of Macrophage, Lymphocyte, and Neutrophil Subtypes Within the Foreign Body Granuloma of Human Mesh Explants by 5-Marker Multiplex Fluorescence Microscopy.Frontiers in medicine · 2022Article
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4 authors.
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Abstract
backgroundPolypropylene (PP) mesh is widely used to reinforce tissues. The foreign body reaction (FBR) to the implant is dominated by innate immune cells, especially macrophages. However, considerable numbers of adaptive immune cells, namely T cells, have also been regularly observed, which appear to play a crucial role in the long-term host response.
methodsThis study investigated the FBR to seven human PP meshes, which were removed from the abdomen for recurrence after a median of one year. Using immunofluorescence microscopy, the FBR was examined for various innate (CD11b
resultsT-helper cells (19%) and regulatory T-cells (25%) were present at comparable rates to macrophages, and clustered significantly toward the mesh fibers. For all cell types the lowest proportions of "conventional" cells (< 60%) were observed at the mesh-tissue interface, but increased considerably at about 50-100 µm, indicating reduced stimulation with rising distance to the mesh fibers.
conclusionBoth innate and adaptive immune cells participate in the chronic FBR to PP meshes with T cells and macrophages being the predominant cell types, respectively. In concordance with the previous data, many cells presented a "hybrid" pattern near the mesh fibers. The complexity of the immune reaction seen within the foreign body granuloma may explain why approaches focusing on specific cell types have not been very successful in reducing the chronic FBR.
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