Evidence map›Paper›PMID 33788000›Full record

ArticleActa diabetologica2021

Alterations in Rev-ERBα/BMAL1 ratio and glycated hemoglobin in rotating shift workers: the EuRhythDia study.

Stefano Rizza, Alessio Luzi, Maria Mavilio, Marta Ballanti, Arianna Massimi, Ottavia Porzio, Andrea Magrini, Juliane Hannemann, Rossella Menghini, Michael Lehrke and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta diabetologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Association between Shift Work Schedules and Cardiovascular Events in a Multi-Ethnic Cohort.International journal of environmental research and public health · 2023
    Article
  11. Healthy Sleep Every Day Keeps the Doctor Away.International journal of environmental research and public health · 2022
    Review
  12. Article
  13. Night Shift Work Is Associated with Reduced Rate of Humoral Response Following Vaccination for HBV.International journal of environmental research and public health · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. The Circadian Clock and Obesity.Handbook of experimental pharmacology · 2022
    Article
  18. Article
  19. Physical Activity as a Predictor of the Level of Stress and Quality of Sleep during COVID-19 Lockdown.International journal of environmental research and public health · 2021
    Article
  20. Sleep Quality Is Associated with Vitamin B12 Status in Female Arab Students.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 4 countries.

Stefano RizzaDepartment of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 100133, Rome, Italy.
Alessio LuziDepartment of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 100133, Rome, Italy.
Maria MavilioDepartment of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 100133, Rome, Italy.
Marta BallantiDepartment of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 100133, Rome, Italy.
Arianna MassimiDepartment of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 100133, Rome, Italy.
Ottavia PorzioDepartment of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Andrea MagriniDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Juliane HannemannInstitute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Rossella MenghiniDepartment of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 100133, Rome, Italy.
Michael LehrkeDepartment of Cardiology, University Medical Center Aachen, Aachen, Germany.
Bart StaelsUniv. Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000, Lille, France.
Peter J GrantLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, England.
Rainer H BogerInstitute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nikolaus MarxDepartment of Cardiology, University Medical Center Aachen, Aachen, Germany.
Massimo FedericiDepartment of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 100133, Rome, Italy. federicm@uniroma2.it.ORCID http://orcid.org/0000-0003-4989-5194
University of Rome Tor Vergata · ITUniversität Hamburg · DEInserm · FRUniversity of Leeds · GB

Funding

Deutsche Forschungsgemeinschaft TTR 219European Union's Seventh Framework Programme 278397
6 · The paper itself

Abstract

objectiveTo detect premature gluco-metabolic defects among night shift workers with disturbances in circadian rhythms. DESIGN AND

methodsWe performed a hypothesis-generating, cross-sectional analysis of anthropometric, metabolic, lipid, and inflammation parameters, comparing active (a-NSW, n = 111) and former (f-NSW, n = 98) rotating night shift workers with diurnal workers (controls, n = 69). All participants were hospital nurses. We also evaluated the Pittsburgh Sleep Quality Index (PSQI) and assessed expression of transcription factors REV-ERBα and BMAL1 in peripheral blood mononuclear cells (PBMCs), as indicators of the molecular clock.

resultsBoth a-NSW and f-NSW participants had significantly higher glycated hemoglobin (HbA1c) and white blood cell counts (WBC) (p < 0.001 for both), PSQI global score (p = 0.001) and diastolic blood pressure levels (p = 0.024) compared with controls. Expression of REV-ERBα/BMAL1 RNA in PBMC was significantly higher in a-NSW (p = 0.05) than in f-NSW or control participants. Multivariate regression analysis showed that working status and PSQI were independent determinants of higher HbA1c levels (p < 0.001).

conclusionsWe demonstrated that young, healthy night shift workers show subclinical abnormalities in HbA1c and changes in peripheral clock gene expression.

Indexed as

Gene ExpressionShift Work ScheduleAdultARNTL Transcription FactorsBlood PressureCircadian RhythmCross-Sectional StudiesFemaleGlycated HemoglobinHospitalsHumansInflammationLeukocyte CountLeukocytes, MononuclearMaleMiddle AgedARNTL Transcription FactorsBMAL1 protein, humanGlycated HemoglobinNR1D1 protein, humanNuclear Receptor Subfamily 1, Group D, Member 1RNACircadianDiabetesInsulin resistanceObesity

Identifiers

PMID33788000
PMCPMC8272695
OpenAlexW3146654080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.