ArticleCurrent microbiology2021
Green Formulation of Microbial Biopolyesteric Nanocarriers Toward In Vitro Drug Delivery and Its Characterization.
Article in Current microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Bacterial Polyhydroxyalkanoates-based Therapeutics-delivery Nano-systems.Current medicinal chemistry · 2024Review
- Phenylboronic Acid-Grafted Chitosan Nanocapsules for Effective Delivery and Controllable Release of Natural Antioxidants: Olive Oil and Hydroxytyrosol.Pharmaceutics · 2022Article
- The Synthesis, Characterization and Applications of Polyhydroxyalkanoates (PHAs) and PHA-Based Nanoparticles.Polymers · 2021Review
- Pharmaceutical Approaches on Antimicrobial Resistance: Prospects and Challenges.Antibiotics (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the present study, formulation and characterization of microbial biopolyesteric nanocarrier (MBPNc) was reported for in vitro controlled release of the drugs, viz., amoxicillin and levofloxacin. The synthesis of microbial biopolyester, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticle was done by a triple emulsion method and loaded with amoxicillin and levofloxacin to improve its curative bioavailability. The synthesized MBPNc was found to be spherical in shape with a size range of 50-100 nm which was confirmed through Transmission Electron Microscopy (TEM) analysis. The surface topology and physicochemical characteristics were analyzed by Scanning Electron Microscopy (SEM), Fourier Transform Infrared (FTIR), and X-Ray Diffraction (XRD) spectroscopy. The cell viability % of MBPNc, amoxicillin-loaded MBPNc, and levofloxacin-loaded MBPNc on HEK293 cells at a concentration of 400 µg/ml were found to be 93.43 ± 0.66%, 92.29 ± 0.61%, and 91.53 ± 0.46%, respectively, which confirmed that MBPNc is biocompatible and can be used for biomedical applications without any cytotoxic effect. A significant decrease in the bacterial survival ratio (%) and increase in the zone of inhibition were observed on increasing the concentration of drug-loaded MBPNc against E. coli (ATCC®8739™) and S. aureus (ATCC®23,235™). The in vitro drug delivery study showed controlled release of amoxicillin (99.85 ± 0.15%) and levofloxacin (99.73 ± 0.24%) up to 22 h.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.