ArticleGenetics2021
The timing of human adaptation from Neanderthal introgression.
Article in Genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Genetics and genomics of hybridization.Nature reviews. Genetics · 2026Review
- Archaic adaptive introgression in modern human reproductive genes.Communications biology · 2025Article
- Neanderthal ancestry through time: Insights from genomes of ancient and present-day humans.Science (New York, N.Y.) · 2024Article
- Neandertal ancestry through time: Insights from genomes of ancient and present-day humans.bioRxiv : the preprint server for biology · 2024Article
- The temporal and genomic scale of selection following hybridization.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The temporal and genomic scale of selection following hybridization.bioRxiv : the preprint server for biology · 2023Article
- Admixture has obscured signals of historical hard sweeps in humans.Nature ecology & evolution · 2022Article
- Temporal mapping of derived high-frequency gene variants supports the mosaic nature of the evolution of Homo sapiens.Scientific reports · 2022Article
- Detection of Neanderthal Adaptively Introgressed Genetic Variants That Modulate Reporter Gene Expression in Human Immune Cells.Molecular biology and evolution · 2022Article
- Local adaptation and archaic introgression shape global diversity at human structural variant loci.eLife · 2021Article
- The history and evolution of the Denisovan-Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A genomic region associated with protection against severe COVID-19 is inherited from Neandertals.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Admixture has the potential to facilitate adaptation by providing alleles that are immediately adaptive in a new environment or by simply increasing the long-term reservoir of genetic diversity for future adaptation. A growing number of cases of adaptive introgression are being identified in species across the tree of life, however the timing of selection, and therefore the importance of the different evolutionary roles of admixture, is typically unknown. Here, we investigate the spatio-temporal history of selection favoring Neanderthal-introgressed alleles in modern human populations. Using both ancient and present-day samples of modern humans, we integrate the known demographic history of populations, namely population divergence and migration, with tests for selection. We model how a sweep placed along different branches of an admixture graph acts to modify the variance and covariance in neutral allele frequencies among populations at linked loci. Using a method based on this model of allele frequencies, we study previously identified cases of adaptive Neanderthal introgression. From these, we identify cases in which Neanderthal-introgressed alleles were quickly beneficial and other cases in which they persisted at low frequency for some time. For some of the alleles that persisted at low frequency, we show that selection likely independently favored them later on in geographically separated populations. Our work highlights how admixture with ancient hominins has contributed to modern human adaptation and contextualizes observed levels of Neanderthal ancestry in present-day and ancient samples.
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