Evidence map›Paper›PMID 33787858›Full record

ArticleBlood advances2021

Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation.

L Alexander Liggett, Matthew D Galbraith, Keith P Smith, Kelly D Sullivan, Ross E Granrath, Belinda Enriquez-Estrada, Kohl T Kinning, Jessica R Shaw, Angela L Rachubinski, Joaquin M Espinosa and 1 more

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

L Alexander LiggettDivision of Hematology/Oncology, Boston Children's Hospital, and.
Matthew D GalbraithLinda Crnic Institute for Down Syndrome.
Keith P SmithLinda Crnic Institute for Down Syndrome.
Kelly D SullivanLinda Crnic Institute for Down Syndrome.
Ross E GranrathLinda Crnic Institute for Down Syndrome.
Belinda Enriquez-EstradaLinda Crnic Institute for Down Syndrome.
Kohl T KinningLinda Crnic Institute for Down Syndrome.
Jessica R ShawLinda Crnic Institute for Down Syndrome.
Angela L RachubinskiLinda Crnic Institute for Down Syndrome.
Joaquin M EspinosaLinda Crnic Institute for Down Syndrome.
James DeGregoriLinda Crnic Institute for Down Syndrome.
Broad Institute · USLaboratory of Molecular Genetics · PL

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
Understanding Down Syndrome as an InterferonopathyR01AI150305 · NIAID · UNIVERSITY OF COLORADO DENVER · PI ESPINOSA, JOAQUIN M. · 2019 to 2020
$3.5M
Down Syndrome as a systemic autophagy deficiency disorderR01HD103828 · NICHD · UNIVERSITY OF COLORADO DENVER · PI DEGREGORI, JAMES V, THORBURN, ANDREW M · 2020 to 2020
$2.6M
The Role of Trisomy 21 in Hematopoiesis and LeukemogenesisF31CA196231 · NCI · UNIVERSITY OF COLORADO DENVER · PI LIGGETT, LUTHER ALEXANDER · 2015 to 2018
$121k
NCI NIH HHS F31 CA196231NCI NIH HHS P30 CA046934NCRR NIH HHS UL1 RR025780NIAID NIH HHS R01 AI150305NICHD NIH HHS R01 HD103828
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Clonal HematopoiesisDown SyndromeClonal EvolutionHematopoiesisHumans

Identifiers

PMID33787858
PMCPMC8045490
OpenAlexW3142140668

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.