Evidence map›Paper›PMID 33787562›Full record

ArticleFemale pelvic medicine & reconstructive surgery2021

Relationship of Pain Catastrophizing With Urinary Biomarkers in Women With Bladder Pain Syndrome.

Alex Soriano, Antoinette Allen, Anna P Malykhina, Uduak Andy, Heidi Harvie, Lily Arya

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Female pelvic medicine & reconstructive surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Pain Catastrophizing: How Far Have We Come.Neurology international · 2024
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alex SorianoFrom the Division of Urogynecology and Pelvic Reconstructive Surgery, University of Pennsylvania, Philadelphia, PA.
Antoinette AllenFrom the Division of Urogynecology and Pelvic Reconstructive Surgery, University of Pennsylvania, Philadelphia, PA.
Anna P MalykhinaDivision of Urology, Department of Surgery, University of Colorado Denver, Aurora, CO.
Uduak AndyFrom the Division of Urogynecology and Pelvic Reconstructive Surgery, University of Pennsylvania, Philadelphia, PA.
Heidi HarvieFrom the Division of Urogynecology and Pelvic Reconstructive Surgery, University of Pennsylvania, Philadelphia, PA.
Lily AryaFrom the Division of Urogynecology and Pelvic Reconstructive Surgery, University of Pennsylvania, Philadelphia, PA.
University of Pennsylvania · USUniversity of Colorado Denver · US

Funding

Mechanisms of neurogenic bladder dysfunction in a viral murine model of multiple sclerosisR01DK116648 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MALYKHINA, ANNA P · 2020 to 2022
$1.0M
Regulation of pelvic pain and micturition reflex by VEGF in urological chronic pelvic pain syndromeR01DK121506 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MALYKHINA, ANNA P · 2019 to 2021
$700k
NIDDK NIH HHS R01 DK116648NIDDK NIH HHS R01 DK121506
6 · The paper itself

Abstract

objectivesBrain-derived neurotrophic factor (BDNF) has been implicated in central neurological processes. We hypothesize that greater pain catastrophizing is associated with higher urinary BDNF levels in women with bladder pain syndrome.

methodsA secondary analysis of a database of women with urinary urgency was conducted. We identified women who met AUA criteria of bladder pain syndrome. Urinary symptoms, pain catastrophizing, and neuropathic pain were measured using the Female Genitourinary Pain Index, Pain Catastrophizing Scale and painDETECT questionnaires respectively. The relationship of the catastrophizing score with urinary BDNF (primary outcome) and other urinary biomarkers, including nerve growth factor (NGF), vascular endothelial growth factor (VEGF), and osteopontin, was evaluated using univariable and multivariable analyses.

resultsIn 62 women with bladder pain syndrome, 15 (24%) reported pain catastrophizing symptoms (Pain Catastrophizing Scale score >30). Higher catastrophizing scores were associated with worse urinary symptoms, greater pelvic pain, greater neuropathic pain, and worse quality of life scores (all P < 0.01). On multivariable analysis, after controlling for age, body mass index and urinary symptoms, a higher pain catastrophizing score was associated with lower BDNF (P = 0.04) and lower VEGF levels (P = 0.03). Urinary urgency was associated with a higher NGF level (P = 0.04) while bladder pain was associated with higher levels of NGF (P = 0.03) and VEGF (P = 0.01).

conclusionsNeuroinflammatory mechanisms contribute to the central processing of pain in women with bladder pain syndrome. Worse urinary symptoms are associated with higher NGF and VEGF levels, but worse pain catastrophizing is associated with lower BDNF and VEGF levels. Urinary BDNF levels may be useful in phenotyping women who have central augmentation of pain processing.

Indexed as

CatastrophizationCystitis, InterstitialBiomarkersFemaleHumansNerve Growth FactorQuality of LifeVascular Endothelial Growth Factor ABiomarkersNerve Growth FactorVascular Endothelial Growth Factor A

Identifiers

PMID33787562
PMCPMC8449794
OpenAlexW3145930561

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.