ArticleeLife2021
An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex.Nature communications · 2022Pooled it
- Human cortical networks trade communication efficiency for computational reliability.Science advances · 2026Article
- Developmental tuning of functional manifold dimensionality across the human brain.bioRxiv : the preprint server for biology · 2026Article
- Correlation of thalamic functional organization disturbances and genetic architecture in motor subtypes of Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Opportunities and pitfalls of data contextualization in neuroimaging.Nature reviews. Neuroscience · 2026Review
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- The retrieval of previously learned motor memories is facilitated by the reinstatement of default mode network manifold structures.PLoS biology · 2026Article
- Effect of rTMS on cerebral functional hierarchical structure in schizophrenia.Psychoradiology · 2026Article
- Abnormal cortical topographic patterns associated with auditory verbal hallucination in first-episode schizophrenia.Translational psychiatry · 2025Article
- Transfer of motor learning is associated with patterns of activity in the default mode network.PLoS biology · 2025Article
- The multiscale brain structural re-organization that occurs from childhood to adolescence correlates with cortical morphology maturation and functional specialization.PLoS biology · 2025Article
- Functional differentiation of the default and frontoparietal control networks predicts individual differences in creative achievement: evidence from macroscale cortical gradients.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Structural connectome manifold changes related to body mass index and their associations with eating psychopathology.NeuroImage. Clinical · 2025Article
- Structural connectome gradients and their relationship to IQ in childhood.Frontiers in human neuroscience · 2025Article
- From gradients to cognition: linking cortical manifolds to brain flexibility and disorder.Frontiers in cognition · 2025Review
- Disruption of structural connectome hierarchy in age-related hearing loss.Frontiers in neuroscience · 2025Article
- Changes in cortical manifold structure following stroke and its relation to behavioral recovery in the male macaque.Nature communications · 2024Article
- Prognostic model for predicting Alzheimer's disease conversion using functional connectome manifolds.Alzheimer's research & therapy · 2024Article
- Exploring Nonlinear Dynamics In Brain Functionality Through Phase Portraits And Fuzzy Recurrence Plots.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
9 authors at 6 institutions in 4 countries.
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Abstract
Adolescence is a critical time for the continued maturation of brain networks. Here, we assessed structural connectome development in a large longitudinal sample ranging from childhood to young adulthood. By projecting high-dimensional connectomes into compact manifold spaces, we identified a marked expansion of structural connectomes, with strongest effects in transmodal regions during adolescence. Findings reflected increased within-module connectivity together with increased segregation, indicating increasing differentiation of higher-order association networks from the rest of the brain. Projection of subcortico-cortical connectivity patterns into these manifolds showed parallel alterations in pathways centered on the caudate and thalamus. Connectome findings were contextualized via spatial transcriptome association analysis, highlighting genes enriched in cortex, thalamus, and striatum. Statistical learning of cortical and subcortical manifold features at baseline and their maturational change predicted measures of intelligence at follow-up. Our findings demonstrate that connectome manifold learning can bridge the conceptual and empirical gaps between macroscale network reconfigurations, microscale processes, and cognitive outcomes in adolescent development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.