Evidence map›Paper›PMID 33787387›Full record

ArticleEpilepsy currents2021

Proceedings of the Sleep and Epilepsy Workshop: Section 1 Decreasing Seizures-Improving Sleep and Seizures, Themes for Future Research.

Mark Quigg, Carl W Bazil, Melanie Boly, Erik K St Louis, Judy Liu, Louis Ptacek, Rama Maganti, Frank Kalume, Bruce J Gluckman, Jay Pathmanathan and 2 more

Abstract read
In one paragraph

Article in Epilepsy currents, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mark QuiggDepartment of Neurology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Carl W BazilColumbia University, New York, NY, USA.
Melanie BolyDepartment of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Erik K St LouisMayo Clinic, Rochester, MN, USA.
Judy LiuBrown University, Providence, RI, USA.ORCID 0000-0001-9272-9517
Louis PtacekUniversity of California San Francisco, CA, USA.
Rama MagantiDepartment of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.ORCID 0000-0001-5472-1645
Frank KalumeUniversity of Washington, Seattle, WA, USA.
Bruce J GluckmanDepartments of Engineering Science & Mechanics, Neurosurgery, and Biomedical Engineering, Penn State University, University Park, PA, USA.ORCID 0000-0001-7695-2225
Jay PathmanathanUniversity of Pennsylvania, Philadelphia, PA, USA.
Milena K PavlovaDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Gordon F BuchananDepartment of Neurology and Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0003-2371-4455

Funding

Mechanisms of epilepsy-related death in Leigh syndromeR01NS102796 · NINDS · SEATTLE CHILDREN'S HOSPITAL · PI KALUME, FRANCK K · 2017 to 2021
$2.1M
The molecular and genetic basis of myoclonic epilepsyR01NS044379 · NINDS · UNIVERSITY OF UTAH · PI PTACEK, LOUIS J. · 2002 to 2006
$1.8M
NINDS NIH HHS R01 NS044379NINDS NIH HHS R01 NS102796
6 · The paper itself

Abstract

Epileptic seizures, sleep, and circadian timing share bilateral interactions, but concerted work to characterize these interactions and to leverage them to the advantage of patients with epilepsy remains in beginning stages. To further the field, a multidisciplinary group of sleep physicians, epileptologists, circadian timing experts, and others met to outline the state of the art, gaps of knowledge, and suggest ways forward in clinical, translational, and basic research. A multidisciplinary panel of experts discussed these interactions, centered on whether improvements in sleep or circadian rhythms improve decrease seizure frequency. In addition, education about sleep was lacking in among patients, their families, and physicians, and that focus on education was an extremely important "low hanging fruit" to harvest. Improvements in monitoring technology, experimental designs sensitive to the rigor required to dissect sleep versus circadian influences, and clinical trials in seizure reduction with sleep improvements were appropriate.

Indexed as

circadian rhythmepilepsyseizuressleepSUDEP

Identifiers

PMID33787387
PMCPMC8609596

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.