Evidence map›Paper›PMID 33787382›Full record

ArticleInternational journal of immunopathology and pharmacology

Donor-specific antibodies development in renal living-donor receptors: Effect of a single cohort.

Jorge Andrade-Sierra, Alfonso M Cueto-Manzano, Enrique Rojas-Campos, Ernesto Cardona-Muñoz, José I Cerrillos-Gutiérrez, Eduardo González-Espinoza, Luis A Evangelista-Carrillo, Miguel Medina-Pérez, Basilio Jalomo-Martínez, Juan Nieves Hernández and 4 more

Open access · goldAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Jorge Andrade-SierraDepartment of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, México.ORCID https://orcid.org/0000-0002-1663-8223
Alfonso M Cueto-ManzanoMedical Research Unit in Renal Diseases, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, México.
Enrique Rojas-CamposMedical Research Unit in Renal Diseases, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, México.
Ernesto Cardona-MuñozDepartment of Physiology, University Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, México.
José I Cerrillos-GutiérrezDepartment of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, México.
Eduardo González-EspinozaDepartment of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, México.
Luis A Evangelista-CarrilloDepartment of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, México.
Miguel Medina-PérezDepartment of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, México.
Basilio Jalomo-MartínezDepartment of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, México.
Juan Nieves HernándezDepartment of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, México.
Leonardo Pazarín-VillaseñorDepartment of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, México.
Claudia A Mendoza-CerpaDepartment of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, México.
Benjamin Gómez-NavarroDepartment of Nephrology and Organ Transplant Unit, Specialties Hospital, National Western Medical Centre, Mexican Institute of Social Security, Guadalajara, Jalisco, México.
Alejandra G Miranda-DíazDepartment of Physiology, University Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, México.ORCID https://orcid.org/0000-0002-3635-6135
Mexican Social Security Institute · MXUniversidad de Guadalajara · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Minimization in immunosuppression could contribute to the appearance the donor-specific HLA antibodies (DSA) and graft failure. The objective was to compare the incidence of DSA in renal transplantation (RT) in recipients with immunosuppression with and without steroids. A prospective cohort from March 1st, 2013 to March 1st, 2014 and follow-up (1 year), ended in March 2015, was performed in living donor renal transplant (LDRT) recipients with immunosuppression and early steroid withdrawal (ESW) and compared with a control cohort (CC) of patients with steroid-sustained immunosuppression. All patients were negative cross-matched and for DSA pre-transplant. The regression model was used to associate the development of DSA antibodies and acute rejection (AR) in subjects with immunosuppressive regimens with and without steroids. Seventy-seven patients were included (30 ESW and 47 CC). The positivity of DSA class I (13% vs 2%;

Indexed as

Kidney TransplantationLiving DonorsAdolescentAdultAntibodiesAntilymphocyte SerumBasiliximabDrug Administration ScheduleFemaleGraft RejectionHumansImmunosuppression TherapyImmunosuppressive AgentsMaleMethylprednisoloneMiddle AgedAntibodiesAntilymphocyte SerumBasiliximabImmunosuppressive AgentsMethylprednisoloneMycophenolic AcidPrednisoneTacrolimusthymoglobulinacute rejectiondonor-specific antibodiesimmunosuppressionrenal transplantation

Identifiers

PMID33787382
PMCPMC8020398
OpenAlexW3148391297

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.