Evidence map›Paper›PMID 33787337›Full record

ArticleRadiology2021

Longitudinal Trajectories of Regional Cerebral Blood Flow in Very Preterm Infants during Third Trimester Ex Utero Development Assessed with MRI.

Zungho Zun, Kushal Kapse, Marni Jacobs, Sudeepta Basu, Mariam Said, Nicole Andersen, Jonathan Murnick, Taeun Chang, Adre du Plessis, Catherine Limperopoulos

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Early parenteral lipid intake supports cerebellar neurometabolism at term-age in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Observational
  8. Article
  9. Article
  10. Article
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  15. Rapid anatomical imaging of the neonatal brain using TMagnetic resonance in medicine · 2023
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Zungho ZunFrom the Division of Diagnostic Imaging and Radiology, Children's National Hospital, 111 Michigan Ave NW, Washington, DC 20010 (Z.Z., K.K., N.A., J.M., C.L.); Division of Fetal and Transitional Medicine, Children's National Hospital, Washington, DC (Z.Z., A.d.P., C.L.); Departments of Pediatrics (Z.Z., M.J., S.B., M.S., J.M., T.C., A.d.P., C.L.) and Radiology (Z.Z., J.M., C.L.) and Divisions of Neonatology (S.B., M.S.) and Neurology (T.C.), Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC; Division of Biostatistics and Study Methodology, Children's National Research Institute, Washington, DC (M.J.).ORCID 0000-0002-7297-3990
Kushal KapseFrom the Division of Diagnostic Imaging and Radiology, Children's National Hospital, 111 Michigan Ave NW, Washington, DC 20010 (Z.Z., K.K., N.A., J.M., C.L.); Division of Fetal and Transitional Medicine, Children's National Hospital, Washington, DC (Z.Z., A.d.P., C.L.); Departments of Pediatrics (Z.Z., M.J., S.B., M.S., J.M., T.C., A.d.P., C.L.) and Radiology (Z.Z., J.M., C.L.) and Divisions of Neonatology (S.B., M.S.) and Neurology (T.C.), Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC; Division of Biostatistics and Study Methodology, Children's National Research Institute, Washington, DC (M.J.).ORCID 0000-0001-8363-5404
Marni JacobsFrom the Division of Diagnostic Imaging and Radiology, Children's National Hospital, 111 Michigan Ave NW, Washington, DC 20010 (Z.Z., K.K., N.A., J.M., C.L.); Division of Fetal and Transitional Medicine, Children's National Hospital, Washington, DC (Z.Z., A.d.P., C.L.); Departments of Pediatrics (Z.Z., M.J., S.B., M.S., J.M., T.C., A.d.P., C.L.) and Radiology (Z.Z., J.M., C.L.) and Divisions of Neonatology (S.B., M.S.) and Neurology (T.C.), Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC; Division of Biostatistics and Study Methodology, Children's National Research Institute, Washington, DC (M.J.).ORCID 0000-0001-6649-6692
Sudeepta BasuFrom the Division of Diagnostic Imaging and Radiology, Children's National Hospital, 111 Michigan Ave NW, Washington, DC 20010 (Z.Z., K.K., N.A., J.M., C.L.); Division of Fetal and Transitional Medicine, Children's National Hospital, Washington, DC (Z.Z., A.d.P., C.L.); Departments of Pediatrics (Z.Z., M.J., S.B., M.S., J.M., T.C., A.d.P., C.L.) and Radiology (Z.Z., J.M., C.L.) and Divisions of Neonatology (S.B., M.S.) and Neurology (T.C.), Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC; Division of Biostatistics and Study Methodology, Children's National Research Institute, Washington, DC (M.J.).
Mariam SaidFrom the Division of Diagnostic Imaging and Radiology, Children's National Hospital, 111 Michigan Ave NW, Washington, DC 20010 (Z.Z., K.K., N.A., J.M., C.L.); Division of Fetal and Transitional Medicine, Children's National Hospital, Washington, DC (Z.Z., A.d.P., C.L.); Departments of Pediatrics (Z.Z., M.J., S.B., M.S., J.M., T.C., A.d.P., C.L.) and Radiology (Z.Z., J.M., C.L.) and Divisions of Neonatology (S.B., M.S.) and Neurology (T.C.), Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC; Division of Biostatistics and Study Methodology, Children's National Research Institute, Washington, DC (M.J.).ORCID 0000-0002-6938-8424
Nicole AndersenFrom the Division of Diagnostic Imaging and Radiology, Children's National Hospital, 111 Michigan Ave NW, Washington, DC 20010 (Z.Z., K.K., N.A., J.M., C.L.); Division of Fetal and Transitional Medicine, Children's National Hospital, Washington, DC (Z.Z., A.d.P., C.L.); Departments of Pediatrics (Z.Z., M.J., S.B., M.S., J.M., T.C., A.d.P., C.L.) and Radiology (Z.Z., J.M., C.L.) and Divisions of Neonatology (S.B., M.S.) and Neurology (T.C.), Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC; Division of Biostatistics and Study Methodology, Children's National Research Institute, Washington, DC (M.J.).
Jonathan MurnickFrom the Division of Diagnostic Imaging and Radiology, Children's National Hospital, 111 Michigan Ave NW, Washington, DC 20010 (Z.Z., K.K., N.A., J.M., C.L.); Division of Fetal and Transitional Medicine, Children's National Hospital, Washington, DC (Z.Z., A.d.P., C.L.); Departments of Pediatrics (Z.Z., M.J., S.B., M.S., J.M., T.C., A.d.P., C.L.) and Radiology (Z.Z., J.M., C.L.) and Divisions of Neonatology (S.B., M.S.) and Neurology (T.C.), Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC; Division of Biostatistics and Study Methodology, Children's National Research Institute, Washington, DC (M.J.).
Taeun ChangFrom the Division of Diagnostic Imaging and Radiology, Children's National Hospital, 111 Michigan Ave NW, Washington, DC 20010 (Z.Z., K.K., N.A., J.M., C.L.); Division of Fetal and Transitional Medicine, Children's National Hospital, Washington, DC (Z.Z., A.d.P., C.L.); Departments of Pediatrics (Z.Z., M.J., S.B., M.S., J.M., T.C., A.d.P., C.L.) and Radiology (Z.Z., J.M., C.L.) and Divisions of Neonatology (S.B., M.S.) and Neurology (T.C.), Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC; Division of Biostatistics and Study Methodology, Children's National Research Institute, Washington, DC (M.J.).
Adre du PlessisFrom the Division of Diagnostic Imaging and Radiology, Children's National Hospital, 111 Michigan Ave NW, Washington, DC 20010 (Z.Z., K.K., N.A., J.M., C.L.); Division of Fetal and Transitional Medicine, Children's National Hospital, Washington, DC (Z.Z., A.d.P., C.L.); Departments of Pediatrics (Z.Z., M.J., S.B., M.S., J.M., T.C., A.d.P., C.L.) and Radiology (Z.Z., J.M., C.L.) and Divisions of Neonatology (S.B., M.S.) and Neurology (T.C.), Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC; Division of Biostatistics and Study Methodology, Children's National Research Institute, Washington, DC (M.J.).ORCID 0000-0003-3144-8791
Catherine LimperopoulosFrom the Division of Diagnostic Imaging and Radiology, Children's National Hospital, 111 Michigan Ave NW, Washington, DC 20010 (Z.Z., K.K., N.A., J.M., C.L.); Division of Fetal and Transitional Medicine, Children's National Hospital, Washington, DC (Z.Z., A.d.P., C.L.); Departments of Pediatrics (Z.Z., M.J., S.B., M.S., J.M., T.C., A.d.P., C.L.) and Radiology (Z.Z., J.M., C.L.) and Divisions of Neonatology (S.B., M.S.) and Neurology (T.C.), Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC; Division of Biostatistics and Study Methodology, Children's National Research Institute, Washington, DC (M.J.).ORCID 0000-0003-1735-0069
Children's National · US

Funding

Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2016 to 2020
$5.9M
Antecedents of Impaired Brain Development in Fetuses with Heart DiseaseR01HL116585 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI LIMPEROPOULOS, CATHERINE · 2013 to 2017
$3.8M
Impaired Brain Development in a Premature Ex-utero EnvironmentR01HD099393 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI DU PLESSIS, ADRE JACQUES, LIMPEROPOULOS, CATHERINE · 2020 to 2024
$3.4M
Assessment of placental perfusion and oxygenation using novel MRI approaches.R01HD100012 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZUN, ZUNGHO · 2019 to 2022
$2.4M
NHLBI NIH HHS R01 HL116585NICHD NIH HHS R01 HD099393NICHD NIH HHS R01 HD100012NICHD NIH HHS U54 HD090257
6 · The paper itself

Abstract

Background The third trimester of gestation is a crucial phase of rapid brain development, but little has been reported on the trajectories of cerebral blood flow (CBF) in preterm infants in this period. Purpose To quantify regional CBF in very preterm infants longitudinally across the ex utero third trimester and to determine its relationship with clinical factors associated with brain injury and premature birth. Materials and Methods In this prospective study, very preterm infants were enrolled for three longitudinal MRI scans, and 22 healthy full-term infants were enrolled for one term MRI scan between November 2016 and February 2019. Global and regional CBF in the cortical gray matter, white matter, deep gray matter, and cerebellum were measured using arterial spin labeling with postlabeling delay of 2025 msec at 1.5 T and 3.0 T. Brain injury and clinical risk factors in preterm infants were investigated to determine associations with CBF. Generalized estimating equations were used to account for correlations between repeated measures in the same individual. Results A total of 75 preterm infants (mean postmenstrual age [PMA]: 29.5 weeks ± 2.3 [standard deviation], 34.9 weeks ± 0.8, and 39.3 weeks ± 2.0 for each scan; 43 male infants) and 22 full-term infants (mean PMA, 42.1 weeks ± 2.0; 13 male infants) were evaluated. In preterm infants, global CBF was 11.9 mL/100 g/min ± 0.2 (standard error). All regional CBF increased significantly with advancing PMA (

Indexed as

Infant, PrematureCerebral HemorrhageCerebrovascular CirculationDuctus Arteriosus, PatentFemaleGestational AgeHumansInfant, NewbornMagnetic Resonance ImagingMalePregnancyPregnancy Trimester, ThirdProspective StudiesSpin LabelsSpin Labels

Identifiers

PMID33787337
PMCPMC8165945
OpenAlexW3142835600

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.