ArticleJournal of the American Heart Association2021
Chronic Kidney Disease Risk of Isolated Systolic or Diastolic Hypertension in Young Adults: A Nationwide Sample Based-Cohort Study.
Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Early life cookstove interventions and children's blood pressure: Evidence from the Ghana randomized air pollution and health study.Environmental research · 2025Trial
- Risk of Cardiovascular Disease According to Standard Industrial Sectors: A Nationwide Longitudinal Study.Journal of Korean medical science · 2026Article
- Association between job insecurity and cardiovascular diseases in workers with type 2 diabetes mellitus.Scandinavian journal of work, environment & health · 2026Article
- Blood pressure and renal function decline in apparently healthy adults: the tehran lipid and glucose study.Journal of human hypertension · 2026Article
- Nocturnal Stage 1 Hypertension Defined by 2025 Guidelines in Adults With Chronic Kidney Disease.JAMA network open · 2026Article
- Homocysteine levels alter the TyG index-CKD link in Chinese hypertensive patients.BMC nephrology · 2025Observational
- Job Loss and Early-onset Dementia Risk in Middle-aged Adults: A Longitudinal Study.Safety and health at work · 2025Article
- Temporal trends and machine learning prediction for chronic kidney disease due to hypertension in young adults from 1990 to 2021: an analysis of the global burden of disease study 2021.Annals of medicine · 2025Article
- Isolated diastolic hypertension and incident cardio-renal-metabolic multimorbidity in the Tehran Lipid and Glucose Study: comparison of ACC/AHA and ESC/NICE guideline definitions.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Global trends and risk factors of chronic kidney disease in children and young adults from 1990 to 2021: a systematic analysis of the global burden of disease study 2021.Frontiers in public health · 2025Article
- Association Between Triglyceride Glucose Index and Chronic Kidney Disease in Normal-Weight Chinese Adults With Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Cumulative Diastolic Blood Pressure Burden in Normal Systolic Blood Pressure and Cardiovascular Disease.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Blood Pressure Trajectories Through the First Year Postpartum in Overweight or Obese Individuals Following a Hypertensive Disorder of Pregnancy.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Article
- Triglyceride-glucose index predicts future chronic kidney disease development in all populations, including normotensive and isolated diastolic hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Isolated Diastolic Hypertension and Kidney and Cardiovascular Outcomes in CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study.Kidney medicine · 2023Article
- Predicting Changes in Systolic and Diastolic Blood Pressure of Hypertensive Patients in Indonesia Using Machine Learning.Current hypertension reports · 2023Review
- Don't miss the isolated diastolic hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Cross-classification by systolic and diastolic blood pressure levels and chronic kidney disease, proteinuria, or kidney function decline.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- A novel GJA5 variant associated with increased risk of essential hypertension.American journal of translational research · 2023Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Hypertension among young adults is common. However, the effect of isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), or systolic and diastolic hypertension (SDH) among young adults on chronic kidney disease (CKD) development is unknown. Methods and Results From a nationwide health screening database, we included 3 030 884 participants aged 20 to 39 years who were not taking antihypertensives at baseline examination in 2009 to 2010. Participants were categorized as having normal blood pressure (BP), elevated BP, stage 1 IDH, stage 1 ISH, stage 1 SDH, stage 2 IDH, stage 2 ISH, and stage 2 SDH. The primary outcome was incident CKD. A total of 5853 (0.19%) CKD events occurred. With normal BP as the reference, multivariable-adjusted hazard ratios (HRs) (95% CIs) for CKD were 1.14 (95% CI, 1.04-1.26), elevated BP; 1.19 (95% CI, 1.10-1.28), stage 1 IDH; 1.24 (95% CI, 1.08-1.42), stage 1 ISH; 1.39 (95% CI, 1.28-1.51), stage 1 SDH; 1.88 (95% CI, 1.63-2.16), stage 2 IDH; 1.84 (95% CI, 1.54-2.19), stage 2 ISH; 2.70 (95% CI, 2.44-2.98), stage 2 SDH. The HRs for CKD were attenuated in the patients who were antihypertensive and began medication within 1 year of medical checkup than in those without antihypertensives. Conclusions Among Korean young adults, those with elevated BP, stage 1 IDH, stage 1 ISH, stage 1 SDH, stage 2 IDH, stage 2 ISH, and stage 2 SDH were associated with a higher CKD risk than those with normal BP. The CKD risk in ISH and IDH groups was similar but lower than that in the SDH group. Antihypertensives attenuated the risk of CKD in young adults with hypertension.
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