Evidence map›Paper›PMID 33787283›Full record

ArticleJournal of the American Heart Association2021

Fontan-Associated Dyslipidemia.

Adam M Lubert, Tarek Alsaied, Joseph J Palermo, Nadeem Anwar, Elaine M Urbina, Nicole M Brown, Craig Alexander, Hassan Almeneisi, Fred Wu, Andrew R Leventhal and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
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  8. Review
  9. Article
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  11. Review
  12. Article
  13. Body Mass Index Trajectory and Outcome Post Fontan Procedure.Journal of the American Heart Association · 2022
    Article
  14. Fontan-Associated Dyslipidemia.Journal of the American Heart Association · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Adam M LubertDepartment of Pediatrics Cincinnati Children's Hospital Heart InstituteUniversity of Cincinnati College of Medicine Cincinnati OH.
Tarek AlsaiedDepartment of Pediatrics Cincinnati Children's Hospital Heart InstituteUniversity of Cincinnati College of Medicine Cincinnati OH.
Joseph J PalermoDepartment of Pediatrics Division of Gastroenterology Cincinnati Children's Hospital Medical CenterUniversity of Cincinnati College of Medicine Cincinnati OH.
Nadeem AnwarDepartment of Medicine Digestive Disease Division University of Cincinnati College of Medicine Cincinnati OH.
Elaine M UrbinaDepartment of Pediatrics Cincinnati Children's Hospital Heart InstituteUniversity of Cincinnati College of Medicine Cincinnati OH.
Nicole M BrownDepartment of Pediatrics Cincinnati Children's Hospital Heart InstituteUniversity of Cincinnati College of Medicine Cincinnati OH.
Craig AlexanderDepartment of Pediatrics Cincinnati Children's Hospital Heart InstituteUniversity of Cincinnati College of Medicine Cincinnati OH.
Hassan AlmeneisiDepartment of Pediatrics Cincinnati Children's Hospital Heart InstituteUniversity of Cincinnati College of Medicine Cincinnati OH.
Fred WuDepartment of Cardiology Boston Children's HospitalHarvard Medical School Boston MA.
Andrew R LeventhalGill Heart Institute University of Kentucky Lexington KY.
Nael AldweibDepartment of Cardiology Boston Children's HospitalHarvard Medical School Boston MA.
Michael MendelsonDepartment of Cardiology Boston Children's HospitalHarvard Medical School Boston MA.
Alexander R OpotowskyDepartment of Pediatrics Cincinnati Children's Hospital Heart InstituteUniversity of Cincinnati College of Medicine Cincinnati OH.
Cincinnati Children's Hospital Medical Center · USBrigham and Women's Hospital · USBoston Children's Hospital · USUniversity of Cincinnati Medical Center · USUniversity of Kentucky · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
NCATS NIH HHS UL1 TR001102NCRR NIH HHS UL1 RR025758
6 · The paper itself

Abstract

Background Hypocholesterolemia is a marker of liver disease, and patients with a Fontan circulation may have hypocholesterolemia secondary to Fontan-associated liver disease or inflammation. We investigated circulating lipids in adults with a Fontan circulation and assessed the associations with clinical characteristics and adverse events. Methods and Results We enrolled 164 outpatients with a Fontan circulation, aged ≥18 years, in the Boston Adult Congenital Heart Disease Biobank and compared them with 81 healthy controls. The outcome was a combined outcome of nonelective cardiovascular hospitalization or death. Participants with a Fontan (median age, 30.3 [interquartile range, 22.8-34.3 years], 42% women) had lower total cholesterol (149.0±30.1 mg/dL versus 190.8±41.4 mg/dL,

Indexed as

AdultBiomarkersCholesterolDyslipidemiasFemaleFollow-Up StudiesFontan ProcedureHeart Defects, CongenitalHumansIncidenceMaleMiddle AgedPostoperative ComplicationsPrognosisProspective StudiesUnited StatesBiomarkersCholesteroladult congenital heart diseaseFontanhigh‐density lipoprotein cholesterollipidssingle ventricle

Identifiers

PMID33787283
PMCPMC8174355
OpenAlexW3140954466

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.