Evidence map›Paper›PMID 33787087›Full record

ArticleActa ophthalmologica2021

Hypertension affects the treatment of wet age-related macular degeneration.

Ting Wang, Jun Xia, Meng Yuan, Xiaohang Wu, Yi Zhu, Chuan Chen, Sean J Bergunder, Zhenzhen Liu, Wenben Chen, Kai Huang and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta ophthalmologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Vascular remodeling of macular neovascularization following switch to intravitreal faricimab in neovascular AMD.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Ting WangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Jun XiaKey Laboratory of Machine Intelligence and Advanced Computing, Sun Yat-sen University, Guangzhou, China.
Meng YuanState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Xiaohang WuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Yi ZhuDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.
Chuan ChenSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Sean J BergunderJihua laboratory, R&D Center for Ophthalmic Cutting-Edge Technology and Medical Devices, Foshan, Guangdong, China.
Zhenzhen LiuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Wenben ChenState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Kai HuangKey Laboratory of Machine Intelligence and Advanced Computing, Sun Yat-sen University, Guangzhou, China.
Haotian LinState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.ORCID https://orcid.org/0000-0003-4672-9721
Sun Yat-sen University · CNUniversity of Miami · USJi Hua Laboratory · CN

Funding

National Key R&D Program of China 2018YFC0116500
6 · The paper itself

Abstract

purposeDue to population ageing as well as the high prevalence of hypertension and age-related macular degeneration (AMD) in elderly individuals, and the relationship between hypertension and AMD is unclear. Our research aimed to investigate the association between hypertension, wet AMD (wAMD) and the treatment strategy of wAMD patients affected by hypertension.

methodsData of wAMD patients at Zhongshan Ophthalmic Center, Sun Yat-sen University, between 1 January 2002 and 30 June 2019, were extracted from the electronic healthcare information system. wAMD patients were divided into subgroups by hypertension status, age, sex, the need for vitrectomy surgery and the number of anti-VEGF drug intravitreal injections that these were divided in 1-3 vs. >3 (available time from 1 January 2012 to 30 June 2019).

resultsA total of 3096 wAMD patients (41.7% female, 58.3% male) with an age range of 50-96 years (68.7 (SD 9.42) years) were included. wAMD was significantly associated with hypertension (p < 0.001). After adjustment for sex and age, Cox regression model showed a significant association between hypertension in wAMD patients and the number of injections (RR = 1.31, 95% CI: 1.13-1.50, p < 0.001). There was no significant association between hypertension and the need for vitrectomy (p = 0.82).

conclusionswet AMD was associated with hypertension status, and after the regular series of three injections, wAMD patients with hypertension were more likely to receive anti-VEGF drug intravitreal injections than those without hypertension. These results may facilitate prospective research on the prevention of wAMD and contribute to the management of wAMD patients.

Indexed as

Visual AcuityAgedAged, 80 and overAngiogenesis InhibitorsFemaleFollow-Up StudiesHumansHypertensionIntravitreal InjectionsMaleMiddle AgedProspective StudiesRanibizumabTreatment OutcomeVascular Endothelial Growth Factor AVitrectomyAngiogenesis InhibitorsRanibizumabVascular Endothelial Growth Factor Aanti-VEGF treatmenthypertensionvitrectomywet age-related macular degeneration

Identifiers

PMID33787087
PMCPMC9544391
OpenAlexW3143714555

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.