ReviewMolecular ecology2021
Inversion breakpoints and the evolution of supergenes.
Review in Molecular ecology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 92 citations in OpenAlex.
- Parallel adaptation to geothermally-warmed habitats due to common structural variation and functional developmental pathways.Nature communications · 2026Article
- Multiple Origins of a Sex Ratio Supergene in Formica Ants.Molecular biology and evolution · 2026Article
- Recombination suppression in plant adaptation and speciation.The New phytologist · 2026Review
- Examining the Role of a Chromosomal Inversion in Accumulating Adaptive and Barrier Loci in a Cold-adapted Insect Species.Genome biology and evolution · 2026Article
- Glass scallop genome reveals key adaptations to deep-sea environments and ectosymbiosis.Nature communications · 2026Article
- Article
- Rapid genome modifications including chromosomal fusions and large-scale inversions are key features in Arctic codfish species.Genome biology · 2026Article
- Article
- Limited genomic signatures of population collapse in the critically endangered black abalone (Haliotis cracherodii).Molecular ecology · 2025Article
- Chromosome-scale genomes of two wild flowering cherries (Cerasus itosakura and Cerasus jamasakura) provide insights into structural evolution in Cerasus.DNA research : an international journal for rapid publication of reports on genes and genomes · 2025Article
- 3D Genome Constrains Breakpoints of Inversions That Can Act as Barriers to Gene Flow in the Stickleback.Molecular ecology · 2025Article
- Reference genome bias in light of species-specific chromosomal reorganization and translocations.Genome biology · 2025Article
- The Evolution of Locally Adaptive Chromosome Inversions in Mimulus guttatus.Molecular ecology · 2025Article
- Chromosome-Level Genome Assembly of Eden's Whale Clarifies the Taxonomy and Speciation of Bryde's Whale Complex.Molecular biology and evolution · 2025Article
- Genome-wide diversity of chromosomal inversions and their disease relationships.bioRxiv : the preprint server for biology · 2025Article
- Chromosomal Inversions Mediated by Tandem Insertions of Transposable Elements.Genome biology and evolution · 2025Article
- A whole-genome scan for evidence of positive and balancing selection in aye-ayes (Daubentonia madagascariensis) utilizing a well-fit evolutionary baseline model.G3 (Bethesda, Md.) · 2025Article
- Haplotype-resolved genome ofHorticulture research · 2025Article
- Large inversions in Lake Malawi cichlids are associated with habitat preference, lineage, and sex determination.bioRxiv : the preprint server for biology · 2025Article
- Impacts of limits to adaptation on population and community persistence in a changing environment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The coexistence of discrete morphs that differ in multiple traits is common within natural populations of many taxa. Such morphs are often associated with chromosomal inversions, presumably because the recombination suppressing effects of inversions help maintain alternate adaptive combinations of alleles across the multiple loci affecting these traits. However, inversions can also harbour selected mutations at their breakpoints, leading to their rise in frequency in addition to (or independent from) their role in recombination suppression. In this review, we first describe the different ways that breakpoints can create mutations. We then critically examine the evidence for the breakpoint-mutation and recombination suppression hypotheses for explaining the existence of discrete morphs associated with chromosomal inversions. We find that the evidence that inversions are favoured due to recombination suppression is often indirect. The evidence that breakpoints harbour mutations that are adaptive is also largely indirect, with the characterization of inversion breakpoints at the sequence level being incomplete in most systems. Direct tests of the role of suppressed recombination and breakpoint mutations in inversion evolution are thus needed. Finally, we emphasize how the two hypotheses of recombination suppression and breakpoint mutation can act in conjunction, with implications for understanding the emergence of supergenes and their evolutionary dynamics. We conclude by discussing how breakpoint characterization could improve our understanding of complex, discrete phenotypic forms in nature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.