ArticleClinical cardiology2021
High-density lipoprotein cholesterol levels are associated with major adverse cardiovascular events in male but not female patients with hypertension.
Article in Clinical cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01206062 (Systolic Blood Pressure Intervention Trial), which is not on this map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Systolic Blood Pressure Intervention Trial
Who cites it
8 citing papers in PubMed.
- Remnant cholesterol inflammatory index as a novel predictor of cardiovascular disease: Cross-sectional, longitudinal, and cumulative exposure analyses.International journal of cardiology. Heart & vasculature · 2026Article
- Leucine supplementation modulates lipid metabolism and metabolic pathways in mice with type 1 diabetes: A metabolomics study.Experimental and therapeutic medicine · 2026Article
- Sex difference in the relationship between childhood obesity and abnormal lipid profiles in young adults.BMC endocrine disorders · 2025Article
- Article
- Lipoprotein(a) as a novel biomarker for predicting adverse outcomes in ischemic heart failure.Frontiers in cardiovascular medicine · 2024Article
- Combination of coronary CT angiography, FFRClinical cardiology · 2023Article
- Inverse Association between High-Density Lipoprotein Cholesterol and Adverse Outcomes among Acute Ischemic Stroke Patients with Diabetes Mellitus.Biomedicines · 2021Article
- High-density lipoprotein cholesterol levels are associated with major adverse cardiovascular events in male but not female patients with hypertension.Clinical cardiology · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe relationship between high-density lipoprotein cholesterol (HDL-C) levels and major adverse cardiovascular events (MACEs) in hypertensive patients of different sexes is unclear. HYPOTHESIS: Sex differences in the relationship between HDL-C levels and the risk of MACEs among hypertensive patients.
methodsWe performed a post-hoc analysis of data obtained from the Systolic Blood Pressure Intervention Trial (SPRINT) and explored sex-based differences in the relationship between HDL-C levels and MACEs among hypertensive patients using Cox proportional hazards regression.
resultsA total of 9323 hypertensive patients (6016 [64.53%] men and 3307 [35.47%] women) were assessed using SPRINT data. MACEs occurred in 395 (6.57%) men and 166 (5.02%) women after a mean follow-up of 3.26 years. When HDL-C levels were used as a continuous covariate, each 10 mg/dl increase in HDL-C levels decreased the risk of MACEs in men (hazard ratio [HR], 0.78; 95% confidence interval [CI], 0.70-0.88; p < .0001). However, HDL-C levels were not associated with MACEs in female hypertensive patients (HR, 1.02; 95% CI, 0.89-1.16; p = .7869). Compared with those in the first quartile, MACEs in the fourth quartile had the lowest risk among male patients (HR, 0.58; 95% CI, 0.41-0.82; p = .0023). Female patients in the fourth quartile of HDL-C levels had an HR of 1.09 for MACEs (95% CI, 0.62-1.93; p = .7678). HDL-C levels were not associated with the risk of MACEs among females.
conclusionAmong elderly hypertensive patients, higher HDL-C levels were associated with a lower MACE incidence in men but not in women. Unique identifier: NCT01206062.
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