ArticleEnvironmental science and pollution research international2021
Cobalt exposure in relation to cardiovascular disease in the United States general population.
Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Association Between Blood Cobalt Levels and Arteriovenous Fistula Dysfunction in Patients Undergoing Maintenance Hemodialysis: A Multicenter Observational Study.Kidney medicine · 2026Article
- Association of metal and metalloid exposure with cardiovascular-kidney-metabolic syndrome: mediation by inflammation, oxidative stress, and aging.BMC public health · 2025Article
- NDRG1 as a sensor and mediator of endothelial stress: from homeostasis to inflammation and cardiovascular disease.Cellular and molecular life sciences : CMLS · 2025Review
- Associations Between Urinary Metal Levels and Incident Heart Failure: A Multi-Cohort Analysis.JACC. Heart failure · 2025Article
- Occurrence of Potentially Toxic Metals Detected in Milk and Dairy Products in Türkiye: An Assessment in Terms of Human Exposure and Health Risks.Foods (Basel, Switzerland) · 2025Article
- Association of cobalt exposure with all-cause and cardiovascular mortality in U.S. adults.BMC public health · 2025Article
- The Effects of Different Treatments on Serum Trace Element Levels in Dogs with Heart Failure.Animals : an open access journal from MDPI · 2024Article
- Use of biomarkers of metals to improve prediction performance of cardiovascular disease mortality.Environmental health : a global access science source · 2024Article
- Article
- Interactive Effects of Obesity and Hypertension on Patterns of Hair Essential Trace Element and Mineral Content in Adult Women.Biological trace element research · 2023Article
- The association of cobalturia with cobaltism symptoms a prospective blinded study of 229 post-arthroplasty patients.PloS one · 2023Article
- The association between heavy metal exposure and erectile dysfunction in the United States.Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cobalt exposure has adverse health effects on the cardiovascular system in occupational and laboratory studies, but these effects have not been assessed in the general population. We aimed to determine whether serum cobalt levels had relationship with the prevalence of cardiovascular disease (CVD) in the general population. Using data from the National Health and Nutrition Examination Survey (NHANES) (2015-2016), we performed the cross-sectional study. We analyzed the baseline characteristics of 3389 participants (1623 men and 1766 women). Generalized linear models and restricted cubic spline plots curve were undertaken to elucidate the relationship. Stratified subgroup analysis was tested to exclude interaction between different variates and cobalt. Our results showed that the adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for CVD prevalence across the quartiles of cobalt were 0.94 (0.67, 1.30), 1.55 (1.15, 2.10), and 1.74 (1.28, 2.35) compared with lowest quartile. The restricted cubic spline curve also suggested nonlinear and positive association between cobalt and CVD (P for nonlinearity = 0.007). In summary, our cross-sectional results verify that higher cobalt levels are associated with a higher prevalence of cardiovascular disease.
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