Evidence map›Paper›PMID 33786733›Full record

ArticleJournal of assisted reproduction and genetics2021

Establishing a reproductive biorepository for basic and translational research: experience developing the reproductive subjects registry and sample repository.

Samantha B Schon, Nicholas Raja, Min Xu, Heather Cameron, Kun Yang, Jayne Reynolds, Dee Fenner, Erica E Marsh

Abstract read
In one paragraph

Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samantha B SchonDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA. sschon@mail.med.umich.edu.ORCID http://orcid.org/0000-0001-5524-3649
Nicholas RajaDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Min XuDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Heather CameronDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Kun YangDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Jayne ReynoldsDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Dee FennerDivision of Female Pelvic Medicine & Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Erica E MarshDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.

Funding

ELLAS Environment, Leiomyomas, Latinas and Adiposity StudyR01MD011570 · NIMHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARSH, ERICA E · 2016 to 2021
$3.5M
University of Michigan WRHR Career Development ProgramK12HD065257 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FENNER, DEE ELLEN · 2010 to 2019
$3.4M
Study of Ovarian Aging and Reserve in Young Women (SOAR)R01HD088638 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARSH, ERICA E · 2017 to 2022
$3.1M
NICHD NIH HHS K12 HD065257NICHD NIH HHS R01 HD088638NIH HHS 5K12HD065257-10NIH HHS 5R01HD088638-03NIH HHS 5R01MD011570-05NIMHD NIH HHS R01 MD011570
6 · The paper itself

Abstract

purposeTo report experience designing and establishing a reproductive registry and sample biorepository and to describe initial subject characteristics and biospecimens.

methodsBeginning in December 2017, patients presenting for reproductive care at the University of Michigan were approached for study enrollment. Following consent, subjects completed detailed reproductive and health questionnaires. A variety of reproductive specimens and tissues were collected and processed for multiple downstream applications.

resultsSubject enrollment began in December of 2017. There are currently 1798 subjects enrolled. Female participants report a variety of reproductive disorders. Available samples include semen, sperm, follicular fluid, granulosa cells, immature oocytes, ovarian and uterine tissue, and blood samples.

conclusionWe report the successful establishment of a reproductive registry and sample biorepository. Furthermore, we describe methods for collection and storage of a variety of reproductive tissue processed for multiple downstream translational applications.

Indexed as

ReproductionAdolescentAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRegistriesSpecimen HandlingSurveys and QuestionnairesTissue BanksTranslational Research, BiomedicalYoung AdultBiorepositoryIVFPrecision medicineReproductive researchTranslational research

Identifiers

PMID33786733
PMCPMC8417183

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.