Evidence map›Paper›PMID 33786610›Full record

ArticleMolecular medicine reports2021

X‑irradiation induces acute and early term inflammatory responses in atherosclerosis‑prone ApoE‑/‑ mice and in endothelial cells.

Raghda Ramadan, Michaël Claessens, Ellen Cocquyt, Mohamed Mysara, Elke Decrock, Sarah Baatout, An Aerts, Luc Leybaert

Open access · hybridAbstract read
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. METTL3 Modulates Radiation-Induced Cardiac Fibrosis via the Akt/mTOR Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  3. Article
  4. Review
  5. Radiation-Induced Macrovessel/Microvessel Disease.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Raghda RamadanRadiobiology Unit, Belgian Nuclear Research Centre, 2400 Mol, Belgium.
Michaël ClaessensDepartment of Basic and Applied Medical Sciences, Physiology Group, Ghent University, 9000 Ghent, Belgium.
Ellen CocquytDepartment of Basic and Applied Medical Sciences, Physiology Group, Ghent University, 9000 Ghent, Belgium.
Mohamed MysaraMicrobiology Unit, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium.
Elke DecrockDepartment of Basic and Applied Medical Sciences, Physiology Group, Ghent University, 9000 Ghent, Belgium.
Sarah BaatoutRadiobiology Unit, Belgian Nuclear Research Centre, 2400 Mol, Belgium.
An Aerts *Radiobiology Unit, Belgian Nuclear Research Centre, 2400 Mol, Belgium.
Luc Leybaert *Department of Basic and Applied Medical Sciences, Physiology Group, Ghent University, 9000 Ghent, Belgium.
Belgian Nuclear Research Centre · BEGhent University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thoracic radiotherapy is an effective treatment for many types of cancer; however it is also associated with an increased risk of developing cardiovascular disease (CVD), appearing mainly ≥10 years after radiation exposure. The present study investigated acute and early term physiological and molecular changes in the cardiovascular system after ionizing radiation exposure. Female and male ApoE

Indexed as

X-RaysAnimalsApolipoproteins EAtherosclerosisCell Adhesion Molecule-1Cell LineCells, CulturedChemokine CCL2Chemokine CXCL10Endothelial CellsEndothelium, VascularFemaleFibroblast Growth Factor 1Growth Differentiation Factor 15HumansMaleApoe protein, mouseApolipoproteins ECcl2 protein, mouseCell Adhesion Molecule-1Chemokine CCL2Chemokine CXCL10Cxcl10 protein, mouseFibroblast Growth Factor 1Gdf15 protein, mouseGrowth Differentiation Factor 15P-SelectinReceptors, Urokinase Plasminogen Activatoratherosclerosiscardiovascular diseaseendothelial inflammationsystemic inflammationthoracic irradiation

Identifiers

PMID33786610
PMCPMC8025474
OpenAlexW3148408298

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.