Evidence map›Paper›PMID 33786345›Full record

ArticleData in brief2021

Dataset of why inclusion matters for Alzheimer's disease biomarker discovery in plasma.

Mostafa J Khan, Heather Desaire, Oscar L Lopez, M Ilyas Kamboh, Renã A S Robinson

Abstract read
In one paragraph

Article in Data in brief, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Establishing Quality Control Procedures for Large-Scale Plasma Proteomics Analyses.Journal of the American Society for Mass Spectrometry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mostafa J KhanDepartment of Chemistry, Vanderbilt University, 5423 Stevenson Center, Nashville, TN 37235, United States.
Heather DesaireDepartment of Chemistry, University of Kansas, Lawrence, KS 66045, United States.
Oscar L LopezDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, United States.
M Ilyas KambohDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, United States.
Renã A S RobinsonDepartment of Chemistry, Vanderbilt University, 5423 Stevenson Center, Nashville, TN 37235, United States.

Funding

TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, JAMES T. · 1985 to 2019
$43.0M
Research Education ComponentP30AG066468 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOWARD J AIZENSTEIN · 2020 to 2026
$29.4M
Genetic Architecture of Alzheimer’s disease ProteinopathiesR01AG064877 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CRUCHAGA, CARLOS, KAMBOH, M. ILYAS · 2021 to 2024
$8.4M
Search for the Alzheimers GenesR01AG030653 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 2009 to 2019
$7.7M
Deep Resequencing of Candidate Gene Regions in Late-onset Alzheimer's DiseaseR01AG041718 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 2012 to 2016
$3.0M
Genetic Architecture of Alzheimer's disease ProteinopathiesR56AG064877 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CRUCHAGA, CARLOS, KAMBOH, M. ILYAS · 2019 to 2019
$2.6M
Mass Spectrometry Measurements for Complex PTMsR35GM130354 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI DESAIRE, HEATHER R · 2019 to 2023
$1.9M
NIA NIH HHS P30 AG066468NIA NIH HHS P50 AG005133NIA NIH HHS R01 AG030653NIA NIH HHS R01 AG041718NIA NIH HHS R01 AG064877NIA NIH HHS R56 AG064877NIGMS NIH HHS R35 GM130354
6 · The paper itself

Abstract

Here we present a plasma proteomics dataset that was generated to understand the importance of self-reported race for biomarker discovery in Alzheimer's disease. This dataset is related to the article "Why inclusion matters for Alzheimer's disease biomarker discovery in plasma" [1]. Plasma samples were obtained from clinically diagnosed Alzheimer's disease and cognitively normal adults of African American/Black and non-Hispanic White racial and ethnic backgrounds. Plasma was immunodepleted, digested, and isobarically tagged with commercial reagents. Tagged peptides were fractionated using high pH fractionation and resulting fractions analysed by liquid chromatography - mass spectrometry (LC-MS/MS & MS

Indexed as

African AmericanAlzheimer's diseaseBiomarkerBlackdisparitiesPlasmaProteomics

Identifiers

PMID33786345
PMCPMC7988280

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.