Evidence map›Paper›PMID 33786329›Full record

ArticleOrthopaedic journal of sports medicine2021

Comparing Intra-articular Injections of Leukocyte-Poor Platelet-Rich Plasma Versus Low-Molecular Weight Hyaluronic Acid for the Treatment of Symptomatic Osteoarthritis of the Hip: A Double-Blind, Randomized Pilot Study.

Matthew J Kraeutler, Darby A Houck, Tigran Garabekyan, Shannon L Miller, Jason L Dragoo, Omer Mei-Dan

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedic journal of sports medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01920152 (A Randomized Clinical Trial Evaluating Platelet Rich Plasma Versus Hyaluronic-Acid in the Short-term Treatment of Symptomatic OA), which is not on this map. Cited by 23 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 4 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01920152 nacompletednot on this map

A Randomized Clinical Trial Evaluating Platelet Rich Plasma Versus Hyaluronic-Acid in the Short-term Treatment of Symptomatic OA (Osteoarthritis) of the Hip

TypeinterventionalSponsorUniversity of Colorado, DenverRan2013 to 2019Enrolled38ConditionsHip OsteoarthritisArmsPRP, Hyaluronic Acid
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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  14. Platelet-Rich Plasma for Knee and Hip Osteoarthritis Pain: A Scoping Review.Current reviews in musculoskeletal medicine · 2024
    Article
  15. Article
  16. Non-operative Treatment Options for Osteoarthritis in the Hip.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Matthew J KraeutlerDepartment of Orthopedic Surgery, St Joseph's University Medical Center, Paterson, New Jersey, USA.
Darby A HouckDepartment of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Tigran GarabekyanSouthern California Hip Institute, Los Angeles, California, USA.
Shannon L MillerDepartment of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Jason L DragooDepartment of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Omer Mei-DanDepartment of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA.
University of Colorado Denver · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHyaluronic acid (HA) and leukocyte-poor platelet-rich plasma (LP-PRP) are 2 nonoperative treatment options that have been studied in patients with hip osteoarthritis (OA). PURPOSE: To compare the efficacy of intra-articular injections of low-molecular weight (LMW) HA and LP-PRP in patients with hip OA. STUDY

designRandomized controlled trial; Level of evidence, 1.

methodsA total of 34 patients (36 hips) presenting with signs of hip OA were randomized to receive 3 blinded, weekly intra-articular injections of either LP-PRP or LMW-HA. Patients were prospectively evaluated before injections and at 6 weeks and then at 3, 6, 12, and 24 months. The primary outcome, conversion to total hip arthroplasty (THA) or a hip resurfacing procedure, was analyzed along with secondary outcomes including the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score and hip range of motion.

resultsThe final analysis included 33 hips (mean Kellgren-Lawrence grade, 2.73) (LMW-HA: n = 14; LP-PRP: n = 19) in 31 patients (18 male; mean age, 53.8 years). Significantly more patients converted to THA or a hip resurfacing procedure in the LMW-HA group (7/14; 50.0%) (mean, 1.3 years after first injection) than the LP-PRP group (3/19; 15.8%) (mean, 0.73 years after first injection) (

conclusionIntra-articular hip injections of LP-PRP in patients with hip OA resulted in an improvement in WOMAC scores and hip internal rotation at 6 months and delayed the need for THA or a hip resurfacing procedure compared with treatment with LMW-HA. A longer follow-up is necessary to further compare the effects of LP-PRP and LMW-HA injections in patients with hip OA. REGISTRATION: NCT01920152 (ClinicalTrials.gov identifier).

Indexed as

hiphyaluronic acidintra-articular injectionosteoarthritisplatelet-rich plasma

Identifiers

PMID33786329
PMCPMC7934058
OpenAlexW3125683763

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.