Evidence map›Paper›PMID 33786176›Full record

ArticleBiomedical reports2021

Alterations in serum amino acid profiles in children with attention deficit/hyperactivity disorder.

Anatoly V Skalny, Anna L Mazaletskaya, Irina P Zaitseva, Andrey A Skalny, Demetrios A Spandidos, Aristidis Tsatsakis, Yulia N Lobanova, Margarita G Skalnaya, Michael Aschner, Alexey A Tinkov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anatoly V SkalnyLaboratory of Biotechnology and Applied Bioelementology, Yaroslavl State University, Yaroslavl 150000, Russia.
Anna L MazaletskayaLaboratory of Biotechnology and Applied Bioelementology, Yaroslavl State University, Yaroslavl 150000, Russia.
Irina P ZaitsevaLaboratory of Biotechnology and Applied Bioelementology, Yaroslavl State University, Yaroslavl 150000, Russia.
Andrey A SkalnyDepartment of Medical Elementology, Peoples' Friendship University of Russia (RUDN University), Moscow 117198, Russia.
Demetrios A SpandidosLaboratory of Clinical Virology, Medical School, University of Crete, 70013 Heraklion, Greece.
Aristidis TsatsakisLaboratory of Molecular Dietetics, IM Sechenov First Moscow State Medical University, Sechenov University, Moscow 119435, Russia.
Yulia N LobanovaDepartment of Medical Elementology, Peoples' Friendship University of Russia (RUDN University), Moscow 117198, Russia.
Margarita G SkalnayaLaboratory of Biotechnology and Applied Bioelementology, Yaroslavl State University, Yaroslavl 150000, Russia.
Michael AschnerLaboratory of Molecular Dietetics, IM Sechenov First Moscow State Medical University, Sechenov University, Moscow 119435, Russia.
Alexey A TinkovLaboratory of Biotechnology and Applied Bioelementology, Yaroslavl State University, Yaroslavl 150000, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of the present study was to evaluate the circulating serum amino acid levels in children with attention deficit/hyperactivity disorder (ADHD). A total of 71 children with untreated ADHD and 31 neurotypical controls aged 7-14 years old were examined. Serum amino acid levels were evaluated using high-performance liquid chromatography (HPLC) with UV-detection. Laboratory quality control was performed with reference materials of human plasma amino acid levels. The obtained data demonstrated that children with ADHD were characterized by 29, 10 and 20% lower serum histidine (His), glutamine (Gln) and proline (Pro) levels compared with neurotypical children, respectively. In contrast, circulating aspartate (Asp), glutamate (Glu) and hydroxyproline (Hypro) levels exceeded the respective control values by 7, 7 and 42%. Correspondingly, the Gln-to-Glu and Pro-to-Hypro ratios were 28% and 49%, respectively, lower in ADHD cases compared with the controls. Total Gln/Glu levels were also significantly lower in ADHD patients. No significant group differences were observed between the groups in the other amino acids analyzed, including phenylalanine. Multiple linear regression analysis revealed significant associations between circulating serum Gln, lysine (Lys) (both negative) and Glu (positive) levels with total ADHD Rating Scale-IV scores. The observed alterations in Pro/Hypro and Gln/Glu levels and ratios are likely associated with the coexisting connective tissue pathology and alterations in glutamatergic neurotransmission in ADHD, respectively. Altered circulating levels of His, Lys and Asp may also be implicated in ADHD pathogenesis. However, further

Indexed as

attention deficit/hyperactivity disorderglutaminehydroxyprolinelysineneurodevelopmental disorder

Identifiers

PMID33786176
PMCPMC7995246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.