Evidence map›Paper›PMID 33785799›Full record

ArticleScientific reports2021

Hoxd13/Bmp2-mediated mechanism involved in zebrafish finfold design.

João Castro, Vanessa Beviano, Ana Paço, Joana Leitão-Castro, Francisco Cadete, Miguel Francisco, Renata Freitas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Morphogens in the evolution of size, shape and patterning.Development (Cambridge, England) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

João CastroI3S, Institute for Innovation and Health Research, University of Porto, Porto, Portugal.
Vanessa BevianoI3S, Institute for Innovation and Health Research, University of Porto, Porto, Portugal.
Ana PaçoI3S, Institute for Innovation and Health Research, University of Porto, Porto, Portugal.
Joana Leitão-CastroI3S, Institute for Innovation and Health Research, University of Porto, Porto, Portugal.
Francisco CadeteI3S, Institute for Innovation and Health Research, University of Porto, Porto, Portugal.
Miguel FranciscoI3S, Institute for Innovation and Health Research, University of Porto, Porto, Portugal.
Renata FreitasI3S, Institute for Innovation and Health Research, University of Porto, Porto, Portugal. renata.freitas@ibmc.up.pt.ORCID http://orcid.org/0000-0002-0123-7232
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTInstitut de Biologie Moléculaire et Cellulaire · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The overexpression of hoxd13a during zebrafish fin development causes distal endochondral expansion and simultaneous reduction of the finfold, mimicking the major events thought to have happened during the fin-to-limb transition in Vertebrates. We investigated the effect of hoxd13a overexpression on putative downstream targets and found it to cause downregulation of proximal fin identity markers (meis1 and emx2) and upregulation of genes involved in skeletogenesis/patterning (fbn1, dacha) and AER/Finfold maintenance (bmps). We then show that bmp2b overexpression leads to finfold reduction, recapitulating the phenotype observed in hoxd13a-overexpressing fins. In addition, we show that during the development of the long finfold in leo

Indexed as

Gene Expression Regulation, DevelopmentalAnimal FinsAnimalsAnimals, Genetically ModifiedApoptosisBody PatterningBone Morphogenetic Protein 2Down-RegulationEmbryo, NonmammalianHomeodomain ProteinsModels, AnimalModels, BiologicalMutationSignal TransductionSkeletonTranscription Factorsbmp2b protein, zebrafishBone Morphogenetic Protein 2Homeodomain ProteinsHoxd13a protein, zebrafishTranscription FactorsZebrafish Proteins

Identifiers

PMID33785799
PMCPMC8009906
OpenAlexW3145640734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.