ArticleScientific reports2021
A domestic cat whole exome sequencing resource for trait discovery.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Widespread genetic testing controls inherited polycystic kidney disease while avoiding inbreeding in cats.BMC genomics · 2026Article
- Whole Exome Sequencing of Feline Oral Squamous Cell Carcinoma Reveals Genomic Parallels With Human Head and Neck Squamous Cell Carcinoma.Veterinary and comparative oncology · 2026Article
- Whole-genome sequencing of CRFK and PG-4 cells to infer the phenotype of the original donor cats.Companion animal health and genetics · 2026Article
- Review
- Transcriptomes of thirteen healthy feline tissue types.BMC genomics · 2025Article
- Case Report: Budd-Chiari-like syndrome in a cat with polycystic kidney and liver disease.Frontiers in veterinary science · 2025Article
- SomaticHypertension (Dallas, Tex. : 1979) · 2024Article
- Application of Next-Generation Sequencing (NGS) Techniques for Selected Companion Animals.Animals : an open access journal from MDPI · 2024Review
- Article
- Article
- VariantscanR: an R-package as a clinical tool for variant filtering of known phenotype-associated variants in domestic animals.BMC bioinformatics · 2023Article
- Feline precision medicine using whole-exome sequencing identifies a novel frameshift mutation for vitamin D-dependent rickets type 2.Journal of feline medicine and surgery · 2023Article
- Article
- Genomic landscape and gene expression profiles of feline oral squamous cell carcinoma.Frontiers in veterinary science · 2023Article
- Cytogenetic and molecular insight into the genetic background of disorders of sex development in seventeen cats.Scientific reports · 2022Article
- Genetic epidemiology of blood type, disease and trait variants, and genome-wide genetic diversity in over 11,000 domestic cats.PLoS genetics · 2022Article
- A customised target capture sequencing tool for molecular identification of Aloe vera and relatives.Scientific reports · 2021Article
- Feline Polycystic Kidney Disease: An Update.Veterinary sciences · 2021Review
- Neuronal Ceroid Lipofuscinosis in a Domestic Cat Associated with a DNA Sequence Variant That Creates a Premature Stop Codon inG3 (Bethesda, Md.) · 2020Article
- Precision medicine using whole genome sequencing identifies a novel dystrophin (DMD) variant for X-linked muscular dystrophy in a cat.Journal of veterinary internal medicineArticle
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over 94 million domestic cats are susceptible to cancers and other common and rare diseases. Whole exome sequencing (WES) is a proven strategy to study these disease-causing variants. Presented is a 35.7 Mb exome capture design based on the annotated Felis_catus_9.0 genome assembly, covering 201,683 regions of the cat genome. Whole exome sequencing was conducted on 41 cats with known and unknown genetic diseases and traits, of which ten cats had matching whole genome sequence (WGS) data available, used to validate WES performance. At 80 × mean exome depth of coverage, 96.4% of on-target base coverage had a sequencing depth > 20-fold, while over 98% of single nucleotide variants (SNVs) identified by WGS were also identified by WES. Platform-specific SNVs were restricted to sex chromosomes and a small number of olfactory receptor genes. Within the 41 cats, we identified 31 previously known causal variants and discovered new gene candidate variants, including novel missense variance for polycystic kidney disease and atrichia in the Peterbald cat. These results show the utility of WES to identify novel gene candidate alleles for diseases and traits for the first time in a feline model.
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