ArticleNature communications2021
1/f-noise-free optical sensing with an integrated heterodyne interferometer.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- High-Science advances · 2026Article
- Low-frequency ionic-electronic coupling for energy-efficient noise-resilient wireless bioelectronics.Nature communications · 2026Article
- Dual slow-light enhanced photothermal gas spectroscopy on a silicon chip.Nature communications · 2025Article
- Low-Frequency Magnetic Sensing Using Magnetically Modulated Microcavity Resonant Mode.Micromachines · 2025Article
- Towards Point-of-Care Single Biomolecule Detection Using Next Generation Portable Nanoplasmonic Biosensors: A Review.Biosensors · 2024Review
- Review
- Picotesla-sensitivity microcavity optomechanical magnetometry.Light, science & applications · 2024Article
- Ultrasound sensing with optical microcavities.Light, science & applications · 2024Review
- 1/Sensors (Basel, Switzerland) · 2024Article
- On-site airborne pathogen detection for infection risk mitigation.Chemical Society reviews · 2023Review
- Multimode sensing based on optical microcavities.Frontiers of optoelectronics · 2023Review
- Lensfree Air-Quality Monitoring of Fine and Ultrafine Particulate Matter Using Vapor-Condensed Nanolenses.ACS applied nano materials · 2023Article
- On-chip multivariant COVID 19 photonic sensor based on silicon nitride double-microring resonators.Nanophotonics (Berlin, Germany) · 2023Article
- Near single-photon imaging in the shortwave infrared using homodyne detection.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Challenges and perspectives of multi-virus biosensing techniques: A review.Analytica chimica acta · 2023Review
- Wearable bioelectronic masks for wireless detection of respiratory infectious diseases by gaseous media.Matter · 2022Article
- Recent Progress in Silicon-Based Slow-Light Electro-Optic Modulators.Micromachines · 2022Review
- Single-molecule optofluidic microsensor with interface whispering gallery modes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Modelling of the dynamic polarizability of macromolecules for single-molecule optical biosensing.Scientific reports · 2022Article
- Surface Plasmonic Sensors: Sensing Mechanism and Recent Applications.Sensors (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optical evanescent sensors can non-invasively detect unlabeled nanoscale objects in real time with unprecedented sensitivity, enabling a variety of advances in fundamental physics and biological applications. However, the intrinsic low-frequency noise therein with an approximately 1/f-shaped spectral density imposes an ultimate detection limit for monitoring many paramount processes, such as antigen-antibody reactions, cell motions and DNA hybridizations. Here, we propose and demonstrate a 1/f-noise-free optical sensor through an up-converted detection system. Experimentally, in a CMOS-compatible heterodyne interferometer, the sampling noise amplitude is suppressed by two orders of magnitude. It pushes the label-free single-nanoparticle detection limit down to the attogram level without exploiting cavity resonances, plasmonic effects, or surface charges on the analytes. Single polystyrene nanobeads and HIV-1 virus-like particles are detected as a proof-of-concept demonstration for airborne biosensing. Based on integrated waveguide arrays, our devices hold great potentials for multiplexed and rapid sensing of diverse viruses or molecules.
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