Evidence map›Paper›PMID 33785751›Full record

ArticleNature communications2021

Wireless battery free fully implantable multimodal recording and neuromodulation tools for songbirds.

Jokubas Ausra, Stephanie J Munger, Amirhossein Azami, Alex Burton, Roberto Peralta, Julie E Miller, Philipp Gutruf

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jokubas AusraDepartments of Biomedical Engineering, The University of Arizona, Tucson, AZ, USA.ORCID 0000-0002-4860-6197
Stephanie J MungerDepartment of Neuroscience, The University of Arizona, Tucson, AZ, USA.
Amirhossein AzamiDepartments of Biomedical Engineering, The University of Arizona, Tucson, AZ, USA.
Alex BurtonDepartments of Biomedical Engineering, The University of Arizona, Tucson, AZ, USA.
Roberto PeraltaDepartment of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ, USA.ORCID 0000-0003-3429-7466
Julie E MillerDepartment of Neuroscience, The University of Arizona, Tucson, AZ, USA. juliemiller@email.arizona.edu.ORCID 0000-0003-0371-0342
Philipp GutrufDepartments of Biomedical Engineering, The University of Arizona, Tucson, AZ, USA. pgutruf@email.arizona.edu.ORCID 0000-0002-7183-7268
University of Arizona · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2M
Cardiovascular Biomedical Engineering Training GrantT32HL007955 · NHLBI · UNIVERSITY OF ARIZONA · PI BARTON, JENNIFER KEHLET · 2001 to 2020
$5.1M
NCI NIH HHS P30 CA023074NHLBI NIH HHS T32 HL007955
6 · The paper itself

Abstract

Wireless battery free and fully implantable tools for the interrogation of the central and peripheral nervous system have quantitatively expanded the capabilities to study mechanistic and circuit level behavior in freely moving rodents. The light weight and small footprint of such devices enables full subdermal implantation that results in the capability to perform studies with minimal impact on subject behavior and yields broad application in a range of experimental paradigms. While these advantages have been successfully proven in rodents that move predominantly in 2D, the full potential of a wireless and battery free device can be harnessed with flying species, where interrogation with tethered devices is very difficult or impossible. Here we report on a wireless, battery free and multimodal platform that enables optogenetic stimulation and physiological temperature recording in a highly miniaturized form factor for use in songbirds. The systems are enabled by behavior guided primary antenna design and advanced energy management to ensure stable optogenetic stimulation and thermography throughout 3D experimental arenas. Collectively, these design approaches quantitatively expand the use of wireless subdermally implantable neuromodulation and sensing tools to species previously excluded from in vivo real time experiments.

Indexed as

Implantable NeurostimulatorsNervous System Physiological PhenomenaAnimalsBrainOptogeneticsPeripheral NervesReproducibility of ResultsSongbirdsTelemetryWireless Technology

Identifiers

PMID33785751
PMCPMC8009877
OpenAlexW3120477213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.