Evidence map›Paper›PMID 33785649›Full record

ArticleMolecular cancer therapeutics2021

3D Collagen Vascular Tumor-on-a-Chip Mimetics for Dynamic Combinatorial Drug Screening.

Li Wan, Jun Yin, John Skoko, Russell Schwartz, Mei Zhang, Philip R LeDuc, Carola A Neumann

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 12 citations in OpenAlex.

  1. Biomimetic Scaffold-Based 3D Models for Decoding Cancer Biology and Advancing Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Li WanDepartment of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania.
Jun YinDepartment of Developmental Biology, University of Pittsburgh Medical Center Cancer Institute, Magee Womens Research Institute, Pittsburgh, Pennsylvania.
John SkokoDepartment of Pharmacology and Chemical Biology, University of Pittsburgh Medical Center Cancer Institute, Magee Womens Research Institute, Pittsburgh, Pennsylvania.ORCID 0000-0002-1885-6929
Russell SchwartzComputational Biology Department, Carnegie Mellon University, Pittsburgh, Pennsylvania.
Mei ZhangDepartment of Developmental Biology, University of Pittsburgh Medical Center Cancer Institute, Magee Womens Research Institute, Pittsburgh, Pennsylvania.
Philip R LeDucDepartment of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania. neumannc@upmc.edu prl@andrew.cmu.edu.
Carola A NeumannDepartment of Pharmacology and Chemical Biology, University of Pittsburgh Medical Center Cancer Institute, Magee Womens Research Institute, Pittsburgh, Pennsylvania. neumannc@upmc.edu prl@andrew.cmu.edu.
Magee-Womens Research Institute · USCarnegie Mellon University · USPittsburgh Supercomputing Center · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
Role of extracellular matrix in age-related declines of muscle regenerationR01AG061005 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AMBROSIO, FABRISIA, LEDUC, PHILIP R · 2019 to 2023
$2.5M
Inhibition of DNA double strand break repair in TNBC by nitro-fatty acidsR56CA233817 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEUMANN, CAROLA ANKE · 2019 to 2020
$687k
NCI NIH HHS P30 CA047904NCI NIH HHS R56 CA233817NIA NIH HHS R01 AG061005
6 · The paper itself

Abstract

Disease models, including

Indexed as

AnimalsAntineoplastic AgentsDisease Models, AnimalDrug Evaluation, PreclinicalExtracellular MatrixFemaleHumansImaging, Three-DimensionalLab-On-A-Chip DevicesMiceMice, NudeAntineoplastic Agents

Identifiers

PMID33785649
PMCPMC8172531
OpenAlexW3145266074

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.